352535-81-0

352535-81-0 - Names and Identifiers

Name	(4-Bromo-2,6-difluorophenyl)boronic acid
Synonyms	4-Bromo-2,6-difluorophenylboronicacid 4-Bromo-2 6-Difluorophenylboronic Acid 4-Bromo-2,6-difluorophenylboronic acid (4-Bromo-2,6-difluorophenyl)boronic acid Boronic acid,B-(4-broMo-2,6-difluorophenyl)- boronic acid, B-(4-bromo-2,6-difluorophenyl)- 4-Bromo-2,6-difluorophenylboronic acid(Contains varying amounts of anhydride)
CAS	352535-81-0
InChI	InChI=1/C6H4BBrF2O2/c8-3-1-4(9)6(7(11)12)5(10)2-3/h1-2,11-12H

352535-81-0 - Physico-chemical Properties

Molecular Formula	C6H4BBrF2O2
Molar Mass	236.81
Density	1.82±0.1 g/cm3(Predicted)
Melting Point	155-160°C(lit.)
Boling Point	298.4±50.0 °C(Predicted)
Flash Point	134.3°C
Vapor Presure	0.000569mmHg at 25°C
Appearance	Solid
pKa	7.91±0.58(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.547
MDL	MFCD03095369

352535-81-0 - Risk and Safety

Hazard Symbols	Xi - Irritant
WGK Germany	3
Hazard Note	Irritant

352535-81-0 - Introduction

(4-Bromo-2,6-difluorophenyl)boronic acid is an organic compound with the chemical formula C6H4BrBF2O2. It is a white crystalline solid, relatively stable at room temperature.

Regarding its properties, first of all, it has high thermal stability and can be heated at a higher temperature without decomposition. Secondly, it can be dissolved in some organic solvents, such as dimethyl sulfoxide (DMSO), acetonitrile and chloroform. In addition, it is also a weak acid that can react with bases to form the corresponding salts.

(4-Bromo-2,6-difluorophenyl)boronic acid has a wide range of applications in chemical research and synthesis. It is an important organoboron reagent, which can be used in the synthesis of borohydrides, the formation of C- C bonds and the functionalization of electron-rich groups. In addition, it can also be used as a building block for fluorescent dye molecules.

The preparation of (4-Bromo-2,6-difluorophenyl)boronic acid can be carried out in a variety of ways. One of the common methods is the reaction of 4-bromo-2, 6-difluorobenzene with trimethylborane in a reaction solvent, and the product is obtained by a ligand exchange reaction.

Regarding safety information, 4-bromo-2, 6-difluorophenylboronic acid needs to be stored dry, low temperature, and away from oxidizing agents, acids, etc. In the operation, need to wear appropriate protective measures, such as gloves and goggles, to avoid contact with it may cause harm to the human body. At the same time, avoid inhaling its dust or solution, avoid contact with skin and eyes. In case of contact, flush with plenty of water and seek medical help.

Last Update：2024-04-10 22:29:15