35730-78-0
cynaropicrin
CAS: 35730-78-0
Molecular Formula: C19H22O6
35730-78-0 - Names and Identifiers
35730-78-0 - Physico-chemical Properties
| Molecular Formula | C19H22O6 |
| Molar Mass | 346.37 |
| Density | 1.28±0.1 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 566.2±50.0 °C(Predicted) |
| Solubility | Slightly soluble (2.4g/L) (25°C), |
| Appearance | Powder |
| pKa | 13.52±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | Cynaropicrin strongly inhibits lipopolysaccharide-induced TNF-α release from either murine or human macrophage cells in a dose-dependent manner with the IC 50 values of 8.24 and 3.18 μM, respectively. Cynaropicrin shows significant inhibitory effects toward all mitogenic signals with the IC 50 values of 1.20 (concanavalin A), 1.02 (phytohemagglutinin) and 0.90 μM (lipopolysaccharide), respectively. Cynaropicrin suppresses CTLL-2 cell proliferation in a dose-dependent manner and the 50% inhibitory concentration (IC 50 ) of Cynaropicrin for CTLL-2 cell growth is 0.91 μM. The increased mRNA expression of MMP13 induced by TNF-α is similarly inhibited in a concentration-dependent manner by Cynaropicrin. The increased mRNA expression of HIF-2α induced by IL-1β in SW1353 is inhibited in a concentration-dependent manner by Cynaropicrin. |
35730-78-0 - Reference Information
| biological activity | Cynaropicrin is a kind of sesquiterpene lactone, which can inhibit the release of tumor necrosis factor (TNF-α), the IC50 values in murine and human macrophages were 8.24 and 3.18 μm, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and inhibits NF-κB signaling. |
Last Update：2024-04-09 20:52:54
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