35878-28-5

35878-28-5 - Names and Identifiers

Name	CYCLOPENTANE-1,2-DICARBOXYLIC ACID ANHYDRIDE
Synonyms	cis-cyclopentane-1,2-dicarboxylic anhydride CYCLOPENTANE-1,2-DICARBOXYLIC ACID ANHYDRIDE cis-Cyclopentane-1,2-dicarboxylic acid anhydride cis-tetrahydro-1H-cyclopenta[c]furan-1,3(4H)-dione cis-tetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione 3aα,5,6,6aα-Tetrahydro-1H-cyclopenta[c]furan-1,3(4H)-dione 1H-Cyclopenta[c]furan-1,3(3aH)-dione,tetrahydro-, (3aR,6aS)-rel-
CAS	35878-28-5
EINECS	252-773-0

35878-28-5 - Physico-chemical Properties

Molecular Formula	C7H8O3
Molar Mass	140.14
Density	1.309±0.06 g/cm3(Predicted)
Melting Point	73-74 °C
Boling Point	84-86°C/0.5mm
BRN	12396898
Storage Condition	Sealed in dry,Store in freezer, under -20°C

35878-28-5 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R38 - Irritating to the skin R41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.
WGK Germany	3

35878-28-5 - Reference Information

Application

cyclopentane-1, 2-dicarboxylic anhydride is an organic intermediate, 2-dicarboxylic acid was prepared by one-step reaction with acetic anhydride. Cyclopentane -1, 2-dicarboxylic anhydride can be used for the preparation of proline derivatives. Proline is a cyclic imino acid and is the only imino acid of the 20 common amino acids that make up proteins. In the peptide chain has its special role, easy to form CIS peptide bond, is not conducive to the formation of a helix. Proline and its derivatives are widely used in small molecule catalysis and medicinal chemistry. At present, proline and its derivatives are widely used as synthetic building blocks in dipeptidyl peptidase-4 inhibitors (e. G., Vildagliptin, Saxagliptin) and anti-HCV Virus drugs (e. G., Telaprevir, Boceprevir).

preparation

in a ML eggplant-type bottle, add 2g of cis-cyclopentyl -1,2 dicarboxylic acid and 126.4ml of acetic anhydride, the mixture was heated to reflux for 10 hours, and the excess acetic anhydride was removed under reduced pressure to give crude cyclopentane -1, 2-dimethylanhydride.

Last Update：2024-04-09 20:52:54