3597-63-5

3597-63-5 - Names and Identifiers

Name	3-HYDROXY-2H-1,4-BENZOXAZINE-2-ONE
Synonyms	Einecs 222-744-7 4H-1,4-benzoxazine-2,3-dione 4H-1,4-benzoxazine-2,3-quinone 2H-1,4-benzoxazine-2,3(4H)-dione 3-HYDROXY-2H-1,4-BENZOXAZINE-2-ONE 3-Hydroxy-2H-benzo[b][1,4]oxazin-2-one
CAS	3597-63-5
EINECS	222-744-7

3597-63-5 - Physico-chemical Properties

Molecular Formula	C8H5NO3
Molar Mass	163.13
Density	1.402±0.06 g/cm3(Predicted)
Melting Point	258-259 °C(Solv: ethanol (64-17-5))
pKa	9.10±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature

3597-63-5 - Risk and Safety

Hazard Class

IRRITANT

3597-63-5 - Introduction

3-HYDROXY-2H-1,4-BENZOXAZINE-2-ONE is an organic compound with the chemical formula C8H5NO3. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: 3-HYDROXY-2H-1,4-BENZOXAZINE-2-ONE is a white solid.
-Solubility: limited solubility in water, soluble in organic solvents such as chloroform, dichloromethane and dimethyl sulfoxide.
-Melting point: about 170-172 ° C.
-Chemical properties: As a heterocyclic compound, it may participate in various organic reactions.

Use:
- 3-HYDROXY-2H-1,4-BENZOXAZINE-2-ONE has certain applications in the field of medicine. It is used as a pharmaceutical intermediate for the synthesis of some biologically active compounds.
-It can also be used in organic synthesis reactions as a catalyst or starting material.

Method:
The synthesis of 3-HYDROXY-2H-1,4-BENZOXAZINE-2-ONE can usually be carried out by the following steps:
1. Synthesis of 3-amino-2H-benzo [B][1,4] oxazine can be synthesized by the condensation reaction of pyrrolidine tetraone and aniline.
2. Under basic conditions, the amino group in 3-amino-2H-benzo [B][1,4] oxazine is replaced by hydroxyl group by electrophilic substitution reaction to form the target compound 3-HYDROXY-2H-1,4-BENZOXAZINE-2-ONE.

Safety Information:
-Specific toxicity and risk data for 3-HYDROXY-2H-1,4-BENZOXAZINE-2-ONE may be limited. Therefore, when using, must follow the correct laboratory operation method and personal protective measures.
-When handling and storing compounds, care should be taken to avoid contact with skin and eyes and maintain good ventilation. If ingested or inhaled, seek medical attention immediately.
-When using this compound, the relevant regulations and safe operating procedures should be observed.

Last Update：2024-04-09 20:48:19