365997-33-7

365997-33-7 - Names and Identifiers

Name	(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester
Synonyms	(1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylicacidethylester (1S,3R,4R)-3-(Boc-aMino)-4-hydroxy-cyclohexanecarboxylic acid ethyl ester Ethyl(1S,3R,4R)-3-(tert-butoxycarbonylamino)-4-hydroxycyclohexane-1-carboxylate (1S,3R,4R)-(+)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxycyclohexanecarboxylicacidethylester Cyclohexanecarboxylicacid,3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-,ethylester,(1S,3R,4R)-
CAS	365997-33-7

365997-33-7 - Physico-chemical Properties

Molecular Formula	C14H25NO5
Molar Mass	287.352
Density	1.12±0.1 g/cm3(Predicted)
Boling Point	406.6±45.0 °C(Predicted)
Storage Condition	Room Temprature
Physical and Chemical Properties	Acidity coefficient (pKa) 11.73±0.60(Predicted)

365997-33-7 - Introduction

Ethyl (1S,3R,4R)-3-(Boc-aMino)-amino acid ester((1S,3R,4R)-3-(Boc-amino)-4-hydroxycyclohexanecarboxylate) is an organic compound with the following properties:

1. Appearance: Usually colorless or white crystalline solid.
2. melting point: about 50-55 ℃.
3. molecular formula: C, H, NO, and.
4. Molecular weight: 290.37g/mol.

This intermediate is mainly used for the preparation of edoxaban A salt, which is an antiepileptic drug. It is used as a precursor of edu xaban A salt, and the Boc protecting group can be removed by hydrolysis reaction to generate the active compound.

The preparation method can be carried out through the following steps:
1. The Boc-amino group is reacted with ethyl cyclohexenoate under appropriate conditions to produce ethyl cyclohexanecarboxylate having a Boc protecting group.
2. hydrolysis reaction is carried out under alkaline conditions to remove Boc protecting group to generate (1S,3R,4R)-3-(Boc-aMino)-acid ethyl ester.

Regarding safety information, due to the risks and hazards of chemicals, the following are some recommended considerations:
1. Avoid inhalation, ingestion or skin contact with the compound and wear personal protective equipment if necessary.
2. Good laboratory practices and safe operating procedures should be followed during operation.
3. If there is any accident or discomfort, stop using it immediately and seek medical help.
4. In addition, the compound should be stored in a cool and dry place, away from fire and oxidizing agents, and ensure that the storage container is well sealed.

Last Update：2024-04-09 20:52:54