| Molecular Formula | C12H21N |
| Molar Mass | 179.3 |
| Use | N,N-Dimethylamantadine is an amine derivative that can be used as an intermediate in organic synthesis. |
2.151g of 1-bromoadamantane (0.01mol) and 0.978g of dimethylamine hydrochloride (0.012mol) were added to a 100mL high-pressure reactor, solvent 15mL 1,3-dichloropropane was added, stirred at normal temperature for 30 minutes, heated to 165 ℃, and 0.780g of triethylamine (0.0132mol) was slowly added to the system. After 18h of reaction, turn off heating and stirring. Cooling the reaction solution, adding 50% NaOH solution dropwise to adjust the solution to alkaline, extracting with ether (20ml × 3), washing the extraction solution with saturated sodium chloride solution (50ml × 3), and spinning after drying the organic phase of anhydrous magnesium sulfate to obtain a crude product. The crude product was recrystallized from methanol to obtain 1.402g of N,N-dimethylamantadine transparent yellow crystals with a yield of 78.2%.