376592-57-3
5'-chloro-2'-hydroxy-[1,1'-Biphenyl]-3-carboxylic acid
CAS: 376592-57-3
Molecular Formula: C13H9ClO3
376592-57-3 - Names and Identifiers
| Name | 5'-chloro-2'-hydroxy-[1,1'-Biphenyl]-3-carboxylic acid |
| Synonyms | Eltrombopag Impurity 29 5'-Chloro-2'-hydroxybiphenyl-3-carboxylic acid 5'-chloro-2'-hydroxy-[1,1'-Biphenyl]-3-carboxylic acid [1,1'-Biphenyl]-3-carboxylic acid, 5'-chloro-2'-hydroxy- |
| CAS | 376592-57-3 |
| EINECS | 629-877-3 |
376592-57-3 - Physico-chemical Properties
| Molecular Formula | C13H9ClO3 |
| Molar Mass | 248.66 |
| Density | 1.399±0.06 g/cm3(Predicted) |
| Boling Point | 455.3±35.0 °C(Predicted) |
| pKa | 4.02±0.10(Predicted) |
| Storage Condition | 2-8°C |
376592-57-3 - Introduction
5 '-Chloro-2'-hydroxy-[1,1 '-biphenyl]-3-carboxylic acid is an organic compound whose chemical formula is C13H9ClO3. The following is a description of the properties, uses, preparation methods and safety information of the compound:
Nature:
-Appearance: White to yellowish crystalline powder.
-Solubility: Soluble in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane, insoluble in water.
-melting point: about 150-152 ℃.
Use:
5 '-Chloro-2'-hydroxy-[1,1 '-biphenyl]-3-carboxylic acid is mainly used in organic synthesis reactions and can be used as raw materials or intermediates to produce other compounds. Due to its special structure and properties, the compound also has certain application potential in the fields of pharmaceutical research and pesticide synthesis.
Preparation Method:
The preparation method of 5 '-chloro-2'-hydroxy-[1,1 '-biphenyl]-3-carboxylic acid can be carried out by the following steps:
1. Under appropriate conditions, 2-bromobiphenyl reacts with cuprous chloride to generate 2-chlorobiphenyl.
2. the 2-chlorobiphenyl and ketone reducing agent (such as sulfoxyl potassium chloride) reaction, reduction to 2-chlorobenoquinone.
3. react 2-chloro diphenoquinone with an appropriate amount of acidic medium (such as acetic anhydride) to generate the target product 5 '-chloro -2'-hydroxy-[1,1 '-biphenyl]-3-carboxylic acid.
Safety Information:
The following safety precautions are required when using or handling 5 '-chloro-2'-hydroxy-[1,1 '-biphenyl]-3-carboxylic acid:
-The compound may cause irritation to the eyes, skin and respiratory system. Personal protective measures should be taken, such as wearing appropriate protective gloves, masks and protective glasses.
-When operating or contacting the compound, maintain a good ventilation environment and avoid inhaling its vapor or dust.
-Avoid contact with substances such as strong oxidants, strong acids or strong bases to prevent dangerous reactions.
-When using or handling the compound, follow local safe operating procedures, and properly store and dispose of the residue.
Nature:
-Appearance: White to yellowish crystalline powder.
-Solubility: Soluble in organic solvents such as ethanol, dimethyl sulfoxide and dichloromethane, insoluble in water.
-melting point: about 150-152 ℃.
Use:
5 '-Chloro-2'-hydroxy-[1,1 '-biphenyl]-3-carboxylic acid is mainly used in organic synthesis reactions and can be used as raw materials or intermediates to produce other compounds. Due to its special structure and properties, the compound also has certain application potential in the fields of pharmaceutical research and pesticide synthesis.
Preparation Method:
The preparation method of 5 '-chloro-2'-hydroxy-[1,1 '-biphenyl]-3-carboxylic acid can be carried out by the following steps:
1. Under appropriate conditions, 2-bromobiphenyl reacts with cuprous chloride to generate 2-chlorobiphenyl.
2. the 2-chlorobiphenyl and ketone reducing agent (such as sulfoxyl potassium chloride) reaction, reduction to 2-chlorobenoquinone.
3. react 2-chloro diphenoquinone with an appropriate amount of acidic medium (such as acetic anhydride) to generate the target product 5 '-chloro -2'-hydroxy-[1,1 '-biphenyl]-3-carboxylic acid.
Safety Information:
The following safety precautions are required when using or handling 5 '-chloro-2'-hydroxy-[1,1 '-biphenyl]-3-carboxylic acid:
-The compound may cause irritation to the eyes, skin and respiratory system. Personal protective measures should be taken, such as wearing appropriate protective gloves, masks and protective glasses.
-When operating or contacting the compound, maintain a good ventilation environment and avoid inhaling its vapor or dust.
-Avoid contact with substances such as strong oxidants, strong acids or strong bases to prevent dangerous reactions.
-When using or handling the compound, follow local safe operating procedures, and properly store and dispose of the residue.
Last Update：2024-04-09 19:05:53
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Product Name: Eltrombopag Impurity 51 Visit Supplier Webpage Request for quotationCAS: 376592-57-3
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Wechat: 15671228036
Product Name: [1,1'-Biphenyl]-3-carboxylic acid, 5'-chloro-2'-hydroxy- Visit Supplier Webpage Request for quotation
CAS: 376592-57-3
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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CAS: 376592-57-3
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