38213-69-3
Bis(maltolato)oxovanadium(IV)
CAS: 38213-69-3
Molecular Formula: C12H10O7V
38213-69-3 - Names and Identifiers
38213-69-3 - Physico-chemical Properties
| Molecular Formula | C12H10O7V |
| Molar Mass | 317.15 |
| Melting Point | >300°C (dec.) |
| Water Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| Appearance | Morphological powder color yellow to gray to brown |
| Color | yellow to grey to brown |
| Storage Condition | Refrigerator |
| In vitro study | Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells. |
| In vivo study | Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice. Animal Model: C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD) Dosage: 0.75-3.0 mmol Administration: Intraperitoneal injection; twice weekly; for 6 weeks Result: Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance. |
38213-69-3 - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
38213-69-3 - Introduction
Biological activity
BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV)) is an effective oral vanadium complex with anti-diabetic properties and insulin-mimicking effects. BMOV has been shown to improve cardiac dysfunction in diabetic models.
Target
IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)
Last Update：2024-04-10 22:29:15
38213-69-3 - Reference Information
| biological activity | BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV)) is an effective oral vanadium complex with anti-diabetic properties and imitation The effect of insulin. BMOV has been shown to improve cardiac dysfunction in diabetic models. |
| target | IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2) |
| in vitro study | Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells. |
| in vivo study | Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J ice) treatment ameliorates the metabolic phenotype. Living, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analyzed tissues compared to HFD mice. Animal Model: C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD) Dosage: 0.75-3.0 mmol Administration: Intraperitoneal injection; twice weekly; For 6 weeks result: Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance. |
| Animal Model: | C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD) |
| Dosage: | 0.75-3.0 mmol |
| Administration: | Intraperitoneal injection; twice weekly; for 6 weeks |
| Result: | Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance. |
Last Update：2024-04-10 22:29:15
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Product Name: Bis(Maltolato)Oxovanadium(IV) Visit Supplier Webpage Request for quotation
CAS: 38213-69-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 38213-69-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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