Name | 2-[5-(2-Fluorophenyl)-1H-pyrazol-3-yl]-phenol |
Synonyms | VU0420373 2-[5-(2-Fluorophenyl)-1H-pyrazol-3-yl]-phenol |
CAS | 38376-29-3 |
Molecular Formula | C15H11FN2O |
Molar Mass | 254.26 |
Solubility | DMSO: soluble20mg/mg protein, clear |
Appearance | powder |
Color | white to beige |
Storage Condition | 2-8°C |
In vitro study | VU0420373 (compound 2e) has an IC 50 of >60 μM for Newman aerobic and Newman anaerobic, respectively. VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM). |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
WGK Germany | 3 |
biological activity | VU0420373 is a potent activator of the heme Sensor System (HssRS) with an EC50 of 10.7 μm, pEC50 was 4.97. VU0420373 induces heme biosynthesis and is toxic to fermentative Staphylococcus aureus. |
Target | EC50: 10.7 μm (HssRS) pEC50: 4.97 (HssRS) |