38585-62-5
4-Methyl-5-imidazolemethanol hydrochloride
CAS: 38585-62-5
Molecular Formula: C5H9ClN2O
38585-62-5 - Names and Identifiers
38585-62-5 - Physico-chemical Properties
| Molecular Formula | C5H9ClN2O |
| Molar Mass | 148.59 |
| Melting Point | 233°C (dec.)(lit.) |
| Solubility | DMSO (Sparingly), Methanol (Slightly) |
| Appearance | Crystalline Powder |
| Color | Very slightly beige |
| Storage Condition | Inert atmosphere,Room Temperature |
| MDL | MFCD00040986 |
38585-62-5 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29332900 |
38585-62-5 - Reference Information
| use | intermediate of cimetidine (Cimetidine). |
| production method | mix and stir α-chloroacetoacetate, formamide, industrial sulfuric acid and water to raise the temperature to 140±5 ℃, keep the temperature for 5 hours, then cool the temperature to about 50 ℃, adjust the pH to 9 with liquid alkali, cool to 10-0 ℃, let stand overnight, then filter, wash the water to pH = 7.5, and filter dry. Soak and wash the filter cake with acetone, filter and dry, and dry to obtain ethyl 4-methyl-5-imidazoleate. Add it to the mixture of liquid ammonia and metal sodium strips, stir and add methanol dropwise, add ammonium chloride, and heat the ammonia to the end. Isopropanol solution saturated with hydrogen chloride was added and refluxed for 1.5 hours. Cooling to 50 ℃, passing in dry hydrogen chloride to about 2.5 pH of the reaction solution, cooling to 40 ℃, suction filtration, washing with isopropanol, washing filtrate combined with concentration, cooling to below 0 ℃, standing overnight, suction filtration, soaking and washing with acetone, drying to obtain the finished product. 89% yield. |
Last Update：2024-04-10 22:40:09
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