394237-61-7
M77976
CAS: 394237-61-7
Molecular Formula: C17H16N2O3
394237-61-7 - Names and Identifiers
394237-61-7 - Physico-chemical Properties
| Molecular Formula | C17H16N2O3 |
| Molar Mass | 296.32 |
| Density | 1.295±0.06 g/cm3(Predicted) |
| Boling Point | 508.1±50.0 °C(Predicted) |
| Appearance | Solid |
| pKa | 8.55±0.35(Predicted) |
| Storage Condition | 2-8°C，密封，干燥 |
| In vitro study | M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid. M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306 and Thr358 of PDK4. |
394237-61-7 - Reference Information
| biological activity | M77976 is a specific, ATP-competitive inhibitor of Pyruvate dehydrogenase kinase PDK4, the IC50 value of the effect was 648 μm. M77976 has potential for obesity and diabetes research. |
| Target | IC50: 648 μm (PDK4) |
Last Update：2024-04-09 21:04:16
