39718-89-3

Name	rac Alminoprofen
Synonyms	EB 382 Minalfen Minalfene alminoprofen rac Alminoprofen 2-[4-(Methallylamino)phenyl]propanoic acid 4-[(2-Methyl-2-propenyl)amino]hydratropic acid α-Methyl-4-[(2-methyl-2-propenyl)amino]benzeneacetic acid
CAS	39718-89-3
EINECS	254-604-6

Molecular Formula	C13H17NO2
Molar Mass	219.28
Density	1.0697 (rough estimate)
Melting Point	107°
Boling Point	360.1°C (rough estimate)
Solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Light Brown
pKa	4.86±0.50(Predicted)
Storage Condition	-20°C Freezer
Refractive Index	1.5100 (estimate)
In vitro study	Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both sPLA2 but also COX-2. Alminoprofen (from 0 to 50 μM) induces a dose-related inhibitory response on thelevels of PGE2 formed by the CRL-1517 cell line.

Toxicity

LD50 orally in mice: 2400 mg/kg (Dumaitre)

biological activity	Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen has both secretory phospholipase A2 (sPLA2) activity and anti-cyclooxygenase (COX-2) activity.
Animal Model:	Groups of Wistar Rats (Oedema of the paw)
Dosage:	100 mg/kg
Administration:	P.o.
Result:	Exerted a statistically significant dose-dependent antagonist action lasting throughout the 2-hr observation period.

Last Update：2024-04-09 20:52:54

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39718-89-3

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