399-51-9

399-51-9 - Names and Identifiers

Name	6-Fluoroindole
Synonyms	6-FL uoroindoL 6-Fluoroindole 5-fluoro-1H-indole 6-Fluoro-1H-indole 6-FLUORO-2-IODOBENZALDEHYDE 6-FLUOROINDOLE FOR SYNTHESIS 5 G 6-Fluoroindole,6-Fluoro-1H-indole 6-FLUOROINDOLE FOR SYNTHESIS 25 G 6-Fluoroindole in stock Factory
CAS	399-51-9
EINECS	700-113-1
InChI	InChI=1/C8H6FN/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H

399-51-9 - Physico-chemical Properties

Molecular Formula	C8H6FN
Molar Mass	135.14
Density	1.1203 (estimate)
Melting Point	72-76 °C (lit.)
Boling Point	230°C (rough estimate)
Flash Point	109.9°C
Water Solubility	Insoluble
Vapor Presure	0.0226mmHg at 25°C
Appearance	Yellow crystal
Color	Beige-brown
BRN	112192
pKa	16.40±0.30(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Sensitive	Light Sensitive
Refractive Index	1.646
MDL	MFCD00056933
Physical and Chemical Properties	Melting Point 72-77°C water-soluble insoluble

399-51-9 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
FLUKA BRAND F CODES	10
HS Code	29339900
Hazard Class	IRRITANT

399-51-9 - Reference Information

use

6-fluoroindole is an important variety of indole series products. it is an intermediate of antipsychotic drugs. there are many existing synthesis methods. some methods use difficult raw materials and high cost, and some methods use raw materials with high toxicity, some methods use the solvent smell is strong, easy to volatilize, not conducive to environmental protection, so the above methods are only in the laboratory stage, can not be used for large-scale industrial production. 6-fluoroindole can be widely used in the field of medicine and chemical industry, such as the preparation of 6-fluoroindole -3-acetonitrile.

application

6-fluoroindole can be widely used in the field of medicine and chemical industry, such as the preparation of 6-fluoroindole -3-acetonitrile. 6-Fluoroindole-3-acetonitrile is a commonly used pharmaceutical intermediate. The first step of the preparation method is to synthesize 6-fluoroindole: the raw materials 6-fluoroindole, dimethylamine hydrochloride and paraformaldehyde are mixed in a molar ratio of 1:1~1.5: 1~2, and then added to the organic solvent After mixing evenly, it is continuously stirred during the reaction process, and it is heated and refluxed to prepare 6-fluoroindole-3-acetonitrile for later use; the second step is to synthesize 6-fluoroindole-3-acetonitrile: using the first step of the raw materials to prepare 6-fluoroindoleine and sodium cyanide according to the molar ratio of 1: 1~2 ingredients, the raw materials are mixed into an organic solvent, reflux reaction after the evaporation of the solvent, the extraction of the organic layer to 6-fluoroindole -3-acetonitrile. The synthesis route is short and can be completed in only two steps. The raw materials are easily available, the 3-position indole replacement is accurate, the control is convenient and the cost is low, the reaction yield is high, and the high-purity drug intermediate products are prepared, which are suitable for industrial production.

Last Update：2024-04-09 21:54:55

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399-51-9

6-Fluoroindole

CAS: 399-51-9

Molecular Formula: C8H6FN

399-51-9 - Names and Identifiers

399-51-9 - Physico-chemical Properties

399-51-9 - Risk and Safety

399-51-9 - Reference Information

Supplier List

399-51-9 Request for Quotation

6-Fluoroindole

CAS: 399-51-9

Molecular Formula: C8H6FN

399-51-9 - Names and Identifiers

399-51-9 - Physico-chemical Properties

399-51-9 - Risk and Safety

399-51-9 - Reference Information

Supplier List

399-51-9