Name | 6-Fluoroindole |
Synonyms | 6-FL uoroindoL 6-Fluoroindole 5-fluoro-1H-indole 6-Fluoro-1H-indole 6-FLUORO-2-IODOBENZALDEHYDE 6-FLUOROINDOLE FOR SYNTHESIS 5 G 6-Fluoroindole,6-Fluoro-1H-indole 6-FLUOROINDOLE FOR SYNTHESIS 25 G 6-Fluoroindole in stock Factory |
CAS | 399-51-9 |
EINECS | 700-113-1 |
InChI | InChI=1/C8H6FN/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H |
Molecular Formula | C8H6FN |
Molar Mass | 135.14 |
Density | 1.1203 (estimate) |
Melting Point | 72-76 °C (lit.) |
Boling Point | 230°C (rough estimate) |
Flash Point | 109.9°C |
Water Solubility | Insoluble |
Vapor Presure | 0.0226mmHg at 25°C |
Appearance | Yellow crystal |
Color | Beige-brown |
BRN | 112192 |
pKa | 16.40±0.30(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Sensitive | Light Sensitive |
Refractive Index | 1.646 |
MDL | MFCD00056933 |
Physical and Chemical Properties | Melting Point 72-77°C water-soluble insoluble |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
FLUKA BRAND F CODES | 10 |
HS Code | 29339900 |
Hazard Class | IRRITANT |
use | 6-fluoroindole is an important variety of indole series products. it is an intermediate of antipsychotic drugs. there are many existing synthesis methods. some methods use difficult raw materials and high cost, and some methods use raw materials with high toxicity, some methods use the solvent smell is strong, easy to volatilize, not conducive to environmental protection, so the above methods are only in the laboratory stage, can not be used for large-scale industrial production. 6-fluoroindole can be widely used in the field of medicine and chemical industry, such as the preparation of 6-fluoroindole -3-acetonitrile. |
application | 6-fluoroindole can be widely used in the field of medicine and chemical industry, such as the preparation of 6-fluoroindole -3-acetonitrile. 6-Fluoroindole-3-acetonitrile is a commonly used pharmaceutical intermediate. The first step of the preparation method is to synthesize 6-fluoroindole: the raw materials 6-fluoroindole, dimethylamine hydrochloride and paraformaldehyde are mixed in a molar ratio of 1:1~1.5: 1~2, and then added to the organic solvent After mixing evenly, it is continuously stirred during the reaction process, and it is heated and refluxed to prepare 6-fluoroindole-3-acetonitrile for later use; the second step is to synthesize 6-fluoroindole-3-acetonitrile: using the first step of the raw materials to prepare 6-fluoroindoleine and sodium cyanide according to the molar ratio of 1: 1~2 ingredients, the raw materials are mixed into an organic solvent, reflux reaction after the evaporation of the solvent, the extraction of the organic layer to 6-fluoroindole -3-acetonitrile. The synthesis route is short and can be completed in only two steps. The raw materials are easily available, the 3-position indole replacement is accurate, the control is convenient and the cost is low, the reaction yield is high, and the high-purity drug intermediate products are prepared, which are suitable for industrial production. |