3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym
(-)-INDOLACTAM V
CAS: 90365-57-4
Molecular Formula: C17H23N3O2
3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym - Names and Identifiers
3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym - Physico-chemical Properties
| Molecular Formula | C17H23N3O2 |
| Molar Mass | 301.38 |
| Density | 1.166±0.06 g/cm3(Predicted) |
| Boling Point | 584.0±50.0 °C(Predicted) |
| Solubility | DMSO: >10mg/mL, clear |
| Appearance | white powder |
| pKa | 14.39±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| In vitro study | (-)-Indolactam V is a PKC activator, with K i s of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and has antitumor activity. (-)-Indolactam V shows K d s of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), respectively. (-)-Indolactam V (20 nM-5 μM) dose-dependently affects multiple hESC lines, such as HUES 2, 4 and 8. (-)-Indolactam V also increases the mRNA levels of Pdx1, HNF6, PTF1A, SOX9, HB9 and PROX1. In addition, (-)-Indolactam V (300 nM) functions in both mouse and human cells and confirms that some signals for pancreatic development. |
3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym - Risk and Safety
| WGK Germany | 3 |
| RTECS | UY8547000 |
3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.318 ml | 16.59 ml | 33.181 ml |
| 5 mM | 0.664 ml | 3.318 ml | 6.636 ml |
| 10 mM | 0.332 ml | 1.659 ml | 3.318 ml |
| 5 mM | 0.066 ml | 0.332 ml | 0.664 ml |
Last Update：2024-01-02 23:10:35
3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym - Reference Information
| biological activity | (-)-Indolactam V is an activator of PKC, and it is important for p-crd2 (PKC N instead of peptide), the Ki values of γ-CRD2 (pkcγ instead of peptide) are 3.36 nM and 1.03 μm, and the Kd values for PKC C1A and C1B domains are 5.5 nM (δ-c1b), respectively, 7.7 nM (δ-C1B),8.3 nM (δ-C1B),18.9 nM (β-C1A-long),20.8 nM (α-C1A-long),137 nM (β-C1B),138 nM (γ-C1A) and 213 nM (γ-C1B), with anti-tumor activity. |
Last Update：2024-04-10 22:29:15
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Product Name: (-)-INDOLACTAM V Visit Supplier Webpage Request for quotation
CAS: 90365-57-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 90365-57-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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