4,6-dimethoxypyrimidine-2(1H)-thione
4,6-Dimethoxy-2-Mercaptopyrimidine
CAS: 57235-35-5
Molecular Formula: C6H8N2O2S
4,6-dimethoxypyrimidine-2(1H)-thione - Names and Identifiers
4,6-dimethoxypyrimidine-2(1H)-thione - Physico-chemical Properties
| Molecular Formula | C6H8N2O2S |
| Molar Mass | 172.2 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | 56-60°C(lit.) |
| Boling Point | 250.9±50.0 °C(Predicted) |
| Flash Point | 105.6°C |
| Vapor Presure | 0.0211mmHg at 25°C |
| pKa | 8.11±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.584 |
4,6-dimethoxypyrimidine-2(1H)-thione - Risk and Safety
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
4,6-dimethoxypyrimidine-2(1H)-thione - Introduction
4, is an organic compound with the chemical formula C7H8N2O2S.
Nature:
-Appearance: A white crystalline solid.
-Solubility: Soluble in common organic solvents such as ethanol, acetone and chloroform.
-Melting point: about 123-126 degrees Celsius.
-Stability: relatively stable under dry conditions, but prone to discoloration when encountering moisture.
Use:
- 4, can be used as catalyst and intermediate, participate in organic synthesis reaction.
-In the pharmaceutical field, it can be used to synthesize intermediates and active ingredients of certain drugs.
-This compound is also used in material science research, such as the preparation of organometallic complexes and optical materials.
Preparation Method:
4, preparation methods are more diverse, common include the following:
1. pyrimidine reacts with bisacetamidoammonium sulfate in acetic acid to give 4,6-diacetamido pyrimidine. The amide group is then converted to a methoxy group by a nucleophilic substitution reaction using a methoxylating reagent such as methyl iodide to give the 4,6-dimethoxy-2-acetamidopyrimidine. Finally, the amide group is converted to a thiol group by a nucleophilic substitution reaction of a thiol to give the final product.
2. In the presence of mercaptoacetone, sodium thiocyanate reacts with 4,6-diiodopyrimidine to obtain 4,6-dimercapto -2-mercaptopyrimidine. The thiol group was then converted to a methoxy group using methanol and cuprous chloride.
Safety Information:
- 4, may have certain risks to health and the environment, and should pay attention to safe operation when using.
-It may be irritating to the eyes, skin and respiratory system, and should be washed with plenty of water immediately after contact.
-Wear appropriate protective equipment such as lab gloves, goggles and protective clothing during use.
-Store and dispose of the compound to avoid potential harm to humans and the environment.
Nature:
-Appearance: A white crystalline solid.
-Solubility: Soluble in common organic solvents such as ethanol, acetone and chloroform.
-Melting point: about 123-126 degrees Celsius.
-Stability: relatively stable under dry conditions, but prone to discoloration when encountering moisture.
Use:
- 4, can be used as catalyst and intermediate, participate in organic synthesis reaction.
-In the pharmaceutical field, it can be used to synthesize intermediates and active ingredients of certain drugs.
-This compound is also used in material science research, such as the preparation of organometallic complexes and optical materials.
Preparation Method:
4, preparation methods are more diverse, common include the following:
1. pyrimidine reacts with bisacetamidoammonium sulfate in acetic acid to give 4,6-diacetamido pyrimidine. The amide group is then converted to a methoxy group by a nucleophilic substitution reaction using a methoxylating reagent such as methyl iodide to give the 4,6-dimethoxy-2-acetamidopyrimidine. Finally, the amide group is converted to a thiol group by a nucleophilic substitution reaction of a thiol to give the final product.
2. In the presence of mercaptoacetone, sodium thiocyanate reacts with 4,6-diiodopyrimidine to obtain 4,6-dimercapto -2-mercaptopyrimidine. The thiol group was then converted to a methoxy group using methanol and cuprous chloride.
Safety Information:
- 4, may have certain risks to health and the environment, and should pay attention to safe operation when using.
-It may be irritating to the eyes, skin and respiratory system, and should be washed with plenty of water immediately after contact.
-Wear appropriate protective equipment such as lab gloves, goggles and protective clothing during use.
-Store and dispose of the compound to avoid potential harm to humans and the environment.
Last Update：2024-04-09 21:00:56
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