4,9-dimethoxy-7-methylfurano(3,2-g)chromen-5-one

Name	khellin
Synonyms	norkel ammivin khellin ammispasmin ammivisnagen 4,9-dimethoxy-7-methylfurano(3,2-g)chromen-5-one 4,9-dimethoxy-7-methyl-5H-furo[3,2-g]chromen-5-one 4,9-dimethoxy-7-methyl-5-oxo-1,8-dioxabenz-(f)indene 4,9-DIMETHOXY-7-METHYLFURO[3,2-G](1)BENZOPYRAN-5-ONE 2-g)(1)benzopyran-5-one,4,9-dimethoxy-7-methyl-5h-furo( 4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE
CAS	82-02-0
EINECS	201-392-8
InChI	InChI=1/C14H12O5/c1-7-6-9(15)10-11(16-2)8-4-5-18-12(8)14(17-3)13(10)19-7/h4-6H,1-3H3

Molecular Formula	C14H12O5
Molar Mass	260.24
Density	1.1954 (rough estimate)
Melting Point	150154°C
Boling Point	180200°C0.05mm Hg
Flash Point	218.8°C
Water Solubility	247.2g/L(25 ºC)
Solubility	Chloroform (Slightly), Methanol (Slightly)
Vapor Presure	1.88E-09mmHg at 25°C
Appearance	Bright yellow powder
Color	light yellow
Merck	14,5309
BRN	263185
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.4560 (estimate)
MDL	MFCD00005007
In vitro study	Khelline exhibits anti-proliferative activity for MCF-7 cells and Hela cells. Khellin inhibits the pathways of Ca 2+ influx which are activated by both noradrenaline and high K + .

Hazard Symbols	T - Toxic
Risk Codes	R25 - Toxic if swallowed R38 - Irritating to the skin R36/37/38 - Irritating to eyes, respiratory system and skin. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed.
Safety Description	S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	LV1050000
Hazard Class	6.1(b)
Packing Group	III
Toxicity	LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch)

EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
biological activity	Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Anglin) isolated from the seeds of amitriasis (Umbelliferae), it is used to treat a variety of diseases.
Target	IC50: 0.15 µm (EGFR)
category	toxic substances
toxicity grade	high toxicity
Acute toxicity	oral-rat LD50: 68.8 mg kg; Oral-mouse LD50: 50.8 mg/kg
flammability hazard characteristics	flammable; Combustion-induced irritating smoke
storage and transportation characteristics	warehouse ventilation and low temperature drying
extinguishing agent	dry powder, foam, sand, carbon dioxide, water mist

Last Update：2024-04-10 22:29:15

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Product Name: khellin Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Multiple SpecificationsSpot supply

Product Name: Khellin Visit Supplier Webpage Request for quotation
CAS: 82-02-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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4,9-dimethoxy-7-methylfurano(3,2-g)chromen-5-one Request for Quotation