Molecular Formula | C8H11NO |
Molar Mass | 137.18 |
Density | 1.0630 (rough estimate) |
Melting Point | 160-162°C(lit.) |
Boling Point | 175-181°C8mm Hg(lit.) |
Flash Point | 165°C |
JECFA Number | 1590 |
Water Solubility | 1g/95mL (15 ºC) |
Solubility | Soluble in ethanol, slightly soluble in water, benzene, xylene. |
Vapor Presure | 0.000123mmHg at 25°C |
Appearance | Crystal powder |
Color | Clear yellow to orange to slightly brown, may darken on storage |
Merck | 14,9835 |
BRN | 1099914 |
pKa | 9.74(at 25℃) |
Storage Condition | 2-8°C |
Stability | Stable. Incompatible with strong acids, strong oxidizing agents. |
Sensitive | Sensitive to air |
Refractive Index | 1.5849 (estimate) |
MDL | MFCD00008193 |
Physical and Chemical Properties | Melting point 155-163°C boiling point 175-181°C (8 mmHg) water-soluble 1g/95mL (15°C) |
Use | Intermediate of bezafibrate for organic synthesis |
In vitro study | Tyramine is normally broken down in your body by an enzyme called MAO (monoamine oxidase). |
Hazard Symbols | Xi - Irritant![]() |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
WGK Germany | 3 |
RTECS | SJ5950000 |
FLUKA BRAND F CODES | 10-23 |
HS Code | 29214990 |
Toxicity | LD50 intracervical in mouse: 30mg/kg |
Reference Show more | 1. Leng Yixin, Wang Tongtong, Yin Zhibin, etc. Rapid determination of tyramine in rice wine by Laser Desorption/laser Post-ionization mass spectrometry [J]. Chinese Journal of Mass Spectrometry, 2018(1):46-52. 2. Quan Qinghua, Zhang Jiamei, Guo Xiaoyu, Sun Qianqian, Tian Changyu, Song Xingzhuo, Jiang kunxiu, Liu Yonggang, Gao Zengping. Fragmentation Mechanism of N-alkylamide derivatives by mass spectrometry [J]. Journal of Mass Spectrometry, 2020,41(05):402-410. 3. [IF = 5.753] Li Qingzhu et al."Transomic and metabologic Analyses reports That exogenic Methyl Jasmonate regulatory Galanthamine Biosynthesis in Lycoris." Front Plant Sci. 2021 Sep;0:1933 4. [IF = 7.514] Tian-tian Zhou et al."Novel carrier-mediated membrane-assisted three-phase liquid-liquid extraction coupled with liquid chromatography-mass spectrometry for the determination of eight biogenic amines in foods."Food Chem. 2022 Sep;387:132857 5. [IF=4.116] Yang Yan Hui et al."Functional characterization of tyrosine decarboxylase genes that contribute to acteoside biosynthesis in Rehmannia glutinosa."Planta. 2022 Mar;255(3):1-15 6. [IF=5.076] Jiahang Yu et al."A Colorimetric Ag Probe for Food Real-Time Visual Monitoring."Nanomaterials. 2022 Jan;12(9):1389 |
FEMA | 4215 | TYRAMINE |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
application | p-hydroxyphenethylamine is an amine organic substance, which can be used in the fields of medicine and organic synthesis. |
Biological activity | Tyramine (4-hydroxyphenethylamine, para-tyramine, mydrial, uteramin) is a natural trace amine derived from amino acid tyrosine, which is a catecholamine release reagent. |
Target | Value |
hTAAR1 (COS-7 cells) | 34 nM(Ki) |
Use | Used in organic synthesis; Bezafibrate intermediate (Intermediate of bezafibrate) Can enter the end of catecholaminergic (catecholaminergic) as a transmitter of camouflage. |
production method | 1. this product is a tyrosine decarboxylation product, which exists in spoiled animal tissues, mature cheese and ergot. Tyrosine is decomposed or produced by spoilage bacteria. It can also be obtained by reducing p-hydroxyphenyl acetonitrile. 2. Tobacco: OR,27. |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |