4-(4-Fluorophenyl)benzaldehyde - Names and Identifiers
4-(4-Fluorophenyl)benzaldehyde - Physico-chemical Properties
Molecular Formula | C13H9FO
|
Molar Mass | 200.21 |
Density | 1.173±0.06 g/cm3(Predicted) |
Melting Point | 93-97℃ |
Boling Point | 324℃ |
Flash Point | >110°(230°F) |
Vapor Presure | 0.000252mmHg at 25°C |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Sensitive | Air Sensitive |
Refractive Index | 1.59 |
4-(4-Fluorophenyl)benzaldehyde - Risk and Safety
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin.
R51 - Toxic to aquatic organisms
R22 - Harmful if swallowed
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
|
Hazard Class | IRRITANT |
4-(4-Fluorophenyl)benzaldehyde - Introduction
4 '-Fluorobiphenyl-4-carbaldehyde is an organic compound with the formula C13H9FO and a molecular weight of 202.21g/mol. It is a colorless crystalline solid that is solid at room temperature.
The compound has a strong fragrance. Its main use is as an intermediate in organic synthesis, and is widely used in pharmaceutical synthesis, dye synthesis and pesticide synthesis.
The preparation method of 4 '-Fluorobiphenyl-4-carbaldehyde can be obtained by esterification of 4-fluorobenzyl alcohol with benzoyl chloride. The specific preparation steps are as follows:
1. Dissolve 4-fluorobenzyl alcohol and pyrrole in dry dichloromethane;
2. Add triethylamine as a catalyst and cool the reaction mixture to near 0°C;
3. slowly add benzoyl chloride dropwise to the reaction system, and continue to stir the reaction system;
4. after the completion of the reaction, the excess triethylamine in the reaction system is neutralized with water, and the reaction system is washed with saturated brine;
5. removing the solvent from the mixture by rotary evaporation to obtain the crude product;
6. finally purified by crystallization or column chromatography to obtain 4 '-Fluorobiphenyl-4-carbaldehyde.
It is worth noting that the 4 '-Fluorobiphenyl-4-carbaldehyde should be protected during operation to avoid contact with skin and eyes. At the same time, it should be operated in a well-ventilated place to avoid inhaling its vapor. In addition, keep away from fire and oxidizing agents during storage and use.
Last Update:2024-04-09 21:11:58