60992-98-5

60992-98-5 - Names and Identifiers

Name	4'-Fluorobiphenyl-4-carbaldehyde
Synonyms	TIMTEC-BB SBB010212 ASINEX-REAG BAS 05891791 4-Fluoro-4'-formylbiphenyl 4'-Fluorobiphenyl-4-aldehyde 4-(4-FLUOROPHENYL)BENZALDEHYDE 4-(4-Fluorophenyl)benzaldehyde 4'-Fluorobiphenyl-4-carbaldehyde 4'-Fluoro-4-biphenylylcarboxaldehyde 4'-Fluoro[1,1'-biphenyl]-4-carbaldehyde [1,1'-BIPHENYL]-4-CARBOXALDEHYDE, 4'-FLUORO-
CAS	60992-98-5
InChI	InChI=1/C13H9FO/c14-13-7-5-12(6-8-13)11-3-1-10(9-15)2-4-11/h1-9H

60992-98-5 - Physico-chemical Properties

Molecular Formula	C13H9FO
Molar Mass	200.21
Density	1.173±0.06 g/cm3(Predicted)
Melting Point	93-97℃
Boling Point	324℃
Flash Point	>110°(230°F)
Vapor Presure	0.000252mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Sensitive	Air Sensitive
Refractive Index	1.59

60992-98-5 - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R51 - Toxic to aquatic organisms R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Class	IRRITANT

60992-98-5 - Introduction

4 '-Fluorobiphenyl-4-carbaldehyde is an organic compound with the formula C13H9FO and a molecular weight of 202.21g/mol. It is a colorless crystalline solid that is solid at room temperature.

The compound has a strong fragrance. Its main use is as an intermediate in organic synthesis, and is widely used in pharmaceutical synthesis, dye synthesis and pesticide synthesis.

The preparation method of 4 '-Fluorobiphenyl-4-carbaldehyde can be obtained by esterification of 4-fluorobenzyl alcohol with benzoyl chloride. The specific preparation steps are as follows:
1. Dissolve 4-fluorobenzyl alcohol and pyrrole in dry dichloromethane;
2. Add triethylamine as a catalyst and cool the reaction mixture to near 0°C;
3. slowly add benzoyl chloride dropwise to the reaction system, and continue to stir the reaction system;
4. after the completion of the reaction, the excess triethylamine in the reaction system is neutralized with water, and the reaction system is washed with saturated brine;
5. removing the solvent from the mixture by rotary evaporation to obtain the crude product;
6. finally purified by crystallization or column chromatography to obtain 4 '-Fluorobiphenyl-4-carbaldehyde.

It is worth noting that the 4 '-Fluorobiphenyl-4-carbaldehyde should be protected during operation to avoid contact with skin and eyes. At the same time, it should be operated in a well-ventilated place to avoid inhaling its vapor. In addition, keep away from fire and oxidizing agents during storage and use.

Last Update：2024-04-09 21:11:58