4-(2-aminopropan-2-yl)benzonitrile - Risk and Safety
Hazard Class
IRRITANT
4-(2-aminopropan-2-yl)benzonitrile - Introduction
4-(2-Aminopropan-2-yl)benzonitrile is an organic compound with a chemical formula of C11H14N2 and a molecular weight of 170.24. It is a white crystal with a special amino and benzene ring structure. The following is a brief description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-melting point: about 114-115 ℃
-Boiling point: about 290-310 ℃
-Soluble: Soluble in some organic solvents
Use:
- 4-(2-Aminopropan-2-yl)benzonitrile is often used as an important intermediate in organic synthesis and is used to synthesize other organic molecules
-It can be used to prepare drugs and bioactive molecules, such as anti-cancer drugs, etc.
Preparation Method:
The preparation methods of 4-(2-Aminopropan-2-yl)benzonitrile are more diverse. A common method is to synthesize through the following steps:
1.2-Bromoacetophenone is reacted with sodium cyanide in the presence of anhydrous sodium carbonate to obtain 2-(2-bromophenyl) propionitrile.
2.2-(2-Bromophenyl) propionitrile is reacted with isopropylamine in the presence of a ketone or a primary amine to give 4-(2-Aminopropan-2-yl)benzonitrile.
Safety Information:
- 4-(2-Aminopropan-2-yl)benzonitrile may be dangerous under certain conditions, and the specific situation should be determined according to relevant experimental evaluation.
-Follow safety practices during use, such as wearing chemical protective gloves, glasses and protective clothing.
-It must be used in a well-ventilated place to avoid inhaling gas or solution vapor.
-Avoid contact with skin, eyes and clothing. In case of contact, rinse immediately with plenty of water and seek medical attention.
-Please check the safety information related to chemicals in advance and use them in accordance with the correct operation methods.