4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-Indolin-2-one
4-(2-bromoethyl)-3-chloro-1,3 dihydro 2-indoline-2-One
CAS: 120427-95-4
Molecular Formula: C10H9BrClNO
4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-Indolin-2-one - Names and Identifiers
| Name | 4-(2-bromoethyl)-3-chloro-1,3 dihydro 2-indoline-2-One |
| Synonyms | ropiniroleinterMediate 4-(2-BROMOETHYL)-3-CHLORO-1H-INDOL-2(3H)-ONE 4-(2-bromoethyl)-3-chloro-1H-Indol-2(3H)-One 4-(2-Bromoethyl)-3-chloro-1H-Indole-2(3H)-one 4-(2-broMoethyl)-3-chloro-2,3-dihydro-1H-indol-2-one 4-(2'-bromoethyl)-3-chloro-1,3-dihydro-2H-Indol-2-One 4-(2'-BROMOETHYL)-3-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE 4-(2-bromoethyl)-3-chloro-1,3 dihydro 2-indoline-2-One 4-(2'-bromoethyl)-3-chloro-1,3-dihydro-2H-Indole-2-One 4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-Indolin-2-one 4-(2'-BROMOETHYL)-3-CHLORO-1,3-DIHYDRO-2H-INDOLE-2-ONE 4-(2'-Bromoethyl)-3-chloro-1,3-dihydro-2-indoline-2-one 4-(2-BROMOETHYL)-3-CHLORO-1,3 DIHYDRO 2-INDOLINE-2-ONE 4-(2'-bromo-ethyl)-3-chloro-1,3-dichloro-2H-indold-2-ketone |
| CAS | 120427-95-4 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C10H9BrClNO/c11-5-4-6-2-1-3-7-8(6)9(12)10(14)13-7/h1-3,9H,4-5H2,(H,13,14) |
4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-Indolin-2-one - Physico-chemical Properties
| Molecular Formula | C10H9BrClNO |
| Molar Mass | 274.54 |
| Density | 1?+-.0.1 g/cm3(Predicted) |
| Boling Point | 374.7±42.0 °C(Predicted) |
| Flash Point | 180.434°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | 12.08±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.633 |
4-(2-bromoethyl)-3-chloro-1,3-dihydro-2H-Indolin-2-one - Introduction
4-(2 '-Bromoethyl) -3-chloro-1, 3-dichloro-2-indolinone, abbreviated as BICDI, is an organic compound. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: BICDI is a white crystal.
-Solubility: It is soluble in organic solvents, such as dimethyl sulfoxide and dimethyl acetamide, but is almost insoluble in water.
Use:
- BICDI is an important intermediate, widely used in the field of organic synthesis.
-It can be used to prepare various medicines, pesticides, dyes and photosensitive compounds.
Preparation Method:
-The preparation method of BICDI is more complicated. A common synthetic route is to prepare it through the halogenation reaction of indole.
-The synthesis method includes the reaction of phenol and iodoethane to synthesize 2 '-iodoethylphenol, and then react it with bromoethanol to obtain 2'-bromoethylphenol. Next, 2 '-bromoethylphenol is reacted with chloroacetic acid to give 4-(2'-bromoethyl)-3-chloroindole. Finally, 4-(2 '-bromoethyl) -3-chloro-1, 3-dichloro-2-indolinone was obtained by chlorination and ketonization.
Safety Information:
- BICDI is a toxic substance and must be operated under appropriate laboratory conditions.
-Avoid exposure to areas such as skin and eyes during contact, and pay attention to adequate ventilation.
-Wear protective gloves, goggles and respiratory protection when using BICDI.
-If accidental contact occurs, rinse immediately with plenty of water and seek medical attention in time.
Nature:
-Appearance: BICDI is a white crystal.
-Solubility: It is soluble in organic solvents, such as dimethyl sulfoxide and dimethyl acetamide, but is almost insoluble in water.
Use:
- BICDI is an important intermediate, widely used in the field of organic synthesis.
-It can be used to prepare various medicines, pesticides, dyes and photosensitive compounds.
Preparation Method:
-The preparation method of BICDI is more complicated. A common synthetic route is to prepare it through the halogenation reaction of indole.
-The synthesis method includes the reaction of phenol and iodoethane to synthesize 2 '-iodoethylphenol, and then react it with bromoethanol to obtain 2'-bromoethylphenol. Next, 2 '-bromoethylphenol is reacted with chloroacetic acid to give 4-(2'-bromoethyl)-3-chloroindole. Finally, 4-(2 '-bromoethyl) -3-chloro-1, 3-dichloro-2-indolinone was obtained by chlorination and ketonization.
Safety Information:
- BICDI is a toxic substance and must be operated under appropriate laboratory conditions.
-Avoid exposure to areas such as skin and eyes during contact, and pay attention to adequate ventilation.
-Wear protective gloves, goggles and respiratory protection when using BICDI.
-If accidental contact occurs, rinse immediately with plenty of water and seek medical attention in time.
Last Update：2024-04-09 21:00:56
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