4-(3-Methoxyphenyl)-2-pyrimidinamine
4-(3-Methoxyphenyl)pyrimidin-2-amine
CAS: 1158235-36-9
Molecular Formula: C11H11N3O
4-(3-Methoxyphenyl)-2-pyrimidinamine - Names and Identifiers
| Name | 4-(3-Methoxyphenyl)pyrimidin-2-amine |
| Synonyms | 4-(3-Methoxyphenyl)-2-pyrimidinamine 4-(3-Methoxyphenyl)pyrimidin-2-amine 2-Pyrimidinamine, 4-(3-methoxyphenyl)- |
| CAS | 1158235-36-9 |
4-(3-Methoxyphenyl)-2-pyrimidinamine - Physico-chemical Properties
| Molecular Formula | C11H11N3O |
| Molar Mass | 201.22 |
| Density | 1.201±0.06 g/cm3(Predicted) |
| Melting Point | 147-150℃ |
| Boling Point | 425.5±37.0 °C(Predicted) |
| pKa | 3.74±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | IRRITANT |
| MDL | MFCD07381836 |
4-(3-Methoxyphenyl)-2-pyrimidinamine - Risk and Safety
| Hazard Class | IRRITANT |
4-(3-Methoxyphenyl)-2-pyrimidinamine - Introduction
4-(3-Methoxyphenyl)pyrimidin-2-amine is an organic compound with the molecular formula C13H12N4O and a molecular weight of 252.26g/mol.
Nature:
4-(3-Methoxyphenyl)pyrimidin-2-amine is a solid, common as white crystals. It is soluble in most organic solvents at room temperature, such as methanol, chloroform, etc., but slightly soluble in water. This compound is stable in the air, but is easily decomposed by light irradiation.
Use:
4-(3-Methoxyphenyl)pyrimidin-2-amine has a wide range of applications in the field of medicine. It is a tyrosine kinase (TK) inhibitor that inhibits cell proliferation and induces apoptosis. Therefore, it can be used to treat certain cancers, such as breast cancer, lung cancer and gastrointestinal tumors.
Preparation Method:
The preparation of 4-(3-Methoxyphenyl)pyrimidin-2-amine can be obtained by the amination reaction of benzoic acid. Benzoic acid and N-methyl-N'-dimethylaminomethane are first reacted by heating in the presence of an acid catalyst to form 4-(3-Methoxyphenyl)pyrimidin-2-amine. The reaction process requires careful control of reaction conditions and dosage to ensure product purity and yield.
Safety Information:
For any chemical substance, strict safety procedures need to be followed. 4-(3-Methoxyphenyl)pyrimidin-2-amine is relatively stable and safe under general conditions, but still requires careful handling. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help. At the same time, you should ensure that you operate in a well-ventilated environment and avoid inhaling dust from the substance. It is best to use the substance in a chemical laboratory or professional practice.
Nature:
4-(3-Methoxyphenyl)pyrimidin-2-amine is a solid, common as white crystals. It is soluble in most organic solvents at room temperature, such as methanol, chloroform, etc., but slightly soluble in water. This compound is stable in the air, but is easily decomposed by light irradiation.
Use:
4-(3-Methoxyphenyl)pyrimidin-2-amine has a wide range of applications in the field of medicine. It is a tyrosine kinase (TK) inhibitor that inhibits cell proliferation and induces apoptosis. Therefore, it can be used to treat certain cancers, such as breast cancer, lung cancer and gastrointestinal tumors.
Preparation Method:
The preparation of 4-(3-Methoxyphenyl)pyrimidin-2-amine can be obtained by the amination reaction of benzoic acid. Benzoic acid and N-methyl-N'-dimethylaminomethane are first reacted by heating in the presence of an acid catalyst to form 4-(3-Methoxyphenyl)pyrimidin-2-amine. The reaction process requires careful control of reaction conditions and dosage to ensure product purity and yield.
Safety Information:
For any chemical substance, strict safety procedures need to be followed. 4-(3-Methoxyphenyl)pyrimidin-2-amine is relatively stable and safe under general conditions, but still requires careful handling. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help. At the same time, you should ensure that you operate in a well-ventilated environment and avoid inhaling dust from the substance. It is best to use the substance in a chemical laboratory or professional practice.
Last Update：2024-04-09 21:32:53
