4-(4-氨基苯磺酰胺基)-5-甲氧基-6-氯嘧啶

4-(4-氨基苯磺酰胺基)-5-甲氧基-6-氯嘧啶 - Names and Identifiers

Name	4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL) BENZENESULFONAMIDE
Synonyms	4-Sulfanilamide-5-Methoxyl-6-Chloro Pyrimidine 6-Chloro-5-methoxy-4-(sulfanilamido)pyrimidine 4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESNLFONAMIDE 4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL) BENZENESULFONAMIDE 4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL) BENZENESULFONAMIDE(MCP)
CAS	5018-23-5

4-(4-氨基苯磺酰胺基)-5-甲氧基-6-氯嘧啶 - Physico-chemical Properties

Molecular Formula	C11H11ClN4O3S
Molar Mass	314.74804
Density	1.548±0.06 g/cm3(Predicted)
Melting Point	200-202 °C(Solv: water (7732-18-5); ethanol (64-17-5))
Boling Point	531.3±60.0 °C(Predicted)
Appearance	Form Solid, color White to Light Gray
pKa	-0.38±0.10(Predicted)
Storage Condition	Refrigerator
Use	Use is an intermediate of sulfamethoxine.

4-(4-氨基苯磺酰胺基)-5-甲氧基-6-氯嘧啶 - Production method

Use methyl methoxyacetate and diethyl oxalate to condensed with the participation of sodium ethoxide to form methyl methoxybutanone diacid, and then heat to decarbonyl under reduced pressure to obtain methoxymalonic acid Methyl ester, the latter and formamide are condensed with sodium methoxide to obtain 5-methoxy-4, 6-dihydroxypyrimidine disodium, and then neutralized with hydrochloric acid to obtain 5-methoxy-4, 6-dihydroxypyrimidine, then use phosphorus trichloride to chlorinate hydroxyl, and condensation with sulfanilamide sodium salt to prepare the product.

Last Update：2024-04-09 21:01:54