4-(4-Aminophenyl)piperazine
4-Piperazinoaniline
CAS: 67455-41-8
Molecular Formula: C10H15N3
4-(4-Aminophenyl)piperazine - Names and Identifiers
| Name | 4-Piperazinoaniline |
| Synonyms | 4-Piperazinoaniline 4-PIPERAZINOANILINE 4-PIPERAZIN-1-YLANILINE 4-(piperazin-1-yl)aniline 1-(4-Aminophenyl)piperazine 4-(4-Aminophenyl)piperazine 4-(4-AMinophenyl)piperazine 4-PIPERAZIN-1-YL-PHENYLAMINE 1-(4-AMINO-PHENYL)-PIPERAZINE BenzenaMine, 4-(1-piperazinyl)- |
| CAS | 67455-41-8 |
| InChI | InChI=1/C10H15N3/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8,11H2 |
4-(4-Aminophenyl)piperazine - Physico-chemical Properties
| Molecular Formula | C10H15N3 |
| Molar Mass | 177.25 |
| Density | 1.107±0.06 g/cm3(Predicted) |
| Melting Point | 119-123 °C (lit.) |
| Boling Point | 380.2±27.0 °C(Predicted) |
| Flash Point | 183.7°C |
| Vapor Presure | 5.56E-06mmHg at 25°C |
| Appearance | Powder |
| Color | White to purple |
| pKa | 9.12±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.59 |
4-(4-Aminophenyl)piperazine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 2 |
4-(4-Aminophenyl)piperazine - Introduction
4-Piperazinoaniline(4-Piperazinoaniline) is an organic compound with the chemical formula C10H14N2.
Nature:
-Appearance: colorless or light yellow crystal
-Melting point: approx. 92-94°C
-Boiling point: about 273°C (decomposition)
-Solubility: It is almost insoluble in water, but soluble in some organic solvents such as ethers, alcohols and ketones.
-Chemical properties: It is a bifunctional compound, containing aniline and piperazine groups, and is alkaline.
Use:
4-Piperazinoaniline has a wide range of applications in the field of medicine, especially in the synthesis of antibiotics and other drugs. It can be used as a pharmaceutical intermediate for the synthesis of various drugs containing piperazine structures.
Preparation Method:
-A common synthesis method is synthesized by the condensation reaction of p-nitrobenzene and malonyl diimide (Piperazine-2,5-dione). First, under basic conditions, nitrobenzene and malonyldiimide react to form the intermediate 4-(2,5-dioxopentyl) benzenitramine, and under reducing conditions, the intermediate is further reduced to form 4-Piperazinoaniline.
Safety Information:
- 4-Piperazinoaniline can be considered hazardous under normal operating conditions and should be avoided by inhalation, swallowing or contact with skin and eyes.
-Wear protective gloves, safety glasses and protective clothing when using or handling the compound.
-should be operated in a well-ventilated place to avoid its vapor or dust inhalation.
-In case of accidental contact or poisoning, seek medical attention immediately and issue the relevant safety data sheet for reference.
Nature:
-Appearance: colorless or light yellow crystal
-Melting point: approx. 92-94°C
-Boiling point: about 273°C (decomposition)
-Solubility: It is almost insoluble in water, but soluble in some organic solvents such as ethers, alcohols and ketones.
-Chemical properties: It is a bifunctional compound, containing aniline and piperazine groups, and is alkaline.
Use:
4-Piperazinoaniline has a wide range of applications in the field of medicine, especially in the synthesis of antibiotics and other drugs. It can be used as a pharmaceutical intermediate for the synthesis of various drugs containing piperazine structures.
Preparation Method:
-A common synthesis method is synthesized by the condensation reaction of p-nitrobenzene and malonyl diimide (Piperazine-2,5-dione). First, under basic conditions, nitrobenzene and malonyldiimide react to form the intermediate 4-(2,5-dioxopentyl) benzenitramine, and under reducing conditions, the intermediate is further reduced to form 4-Piperazinoaniline.
Safety Information:
- 4-Piperazinoaniline can be considered hazardous under normal operating conditions and should be avoided by inhalation, swallowing or contact with skin and eyes.
-Wear protective gloves, safety glasses and protective clothing when using or handling the compound.
-should be operated in a well-ventilated place to avoid its vapor or dust inhalation.
-In case of accidental contact or poisoning, seek medical attention immediately and issue the relevant safety data sheet for reference.
Last Update：2024-04-09 21:01:54
