4-(4-Nitrophenyl)-1,3-Oxazole

4-(4-Nitrophenyl)-1,3-Oxazole - Names and Identifiers

Name	4-(4-Nitrophenyl)-1,3-oxazole
Synonyms	OZNB Oxazole, 4-(4-nitrophenyl)- 4-(4-Nitrophenyl)-1,3-Oxazole 3,5-dichloro-2-fluoropyridine 4-(4-Nitrophenyl)-1,3-oxazole 4-(1,3-OXAZOL-4-YL)NITRO-BENZENE 4-(1,3-OXAZOLE-4-YL)NITRO-BENZENE Oxazole,4-(p-nitrophenyl)- (7CI,8CI) 4-(1,3-OXAZOLE-4-YL)NITRO-BENZENE(OZNB)
CAS	13382-61-1
InChI	InChI=1/C9H6N2O3/c12-11(13)8-3-1-7(2-4-8)9-5-14-6-10-9/h1-6H

4-(4-Nitrophenyl)-1,3-Oxazole - Physico-chemical Properties

Molecular Formula	C9H6N2O3
Molar Mass	190.16
Density	1.333±0.06 g/cm3(Predicted)
Melting Point	186-188 °C(Solv: methanol (67-56-1))
Boling Point	352.6±17.0 °C(Predicted)
Flash Point	167.045°C
Vapor Presure	0mmHg at 25°C
pKa	-0.91±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.585

4-(4-Nitrophenyl)-1,3-Oxazole - Introduction

4-(4-Nitrophenyl) oxazole is an organic compound containing nitro and phenyl substituents. Its molecular formula is C11H7N3O2, which can be abbreviated as NBD-NO2.

The compound has the following properties:
1. Appearance: 4-(4-Nitrophenyl) oxazole is a yellow to orange solid.
2. melting point: its melting point is 120-121 degrees Celsius.
3. Solubility: Soluble in organic solvents such as chloroform, dichloromethane and ethanol.

4-(4-Nitrophenyl) oxazole is commonly used for the following:
1. Military use: Due to its bomb characteristics, it is widely used as an intermediate for explosives and gunpowder.
2. Chemical experiments: It can also be used as a reagent in chemical laboratories for organic synthesis and coordination chemistry.
3. Microscopic labeling: In the biomedical field, 4-(4-nitrophenyl) oxazole is also used as a marker in microscopy.

There are two main methods for preparing the compound:
1. Taking benzyl nitrate and oxazole as raw materials, condensation reaction was carried out in n-propanol solvent, then acylation was carried out with acetyl chloride, and finally the target product was obtained by hydrolysis reaction.
2. first, 4-nitrochlorobenzene and oxazole were reacted to prepare azo compounds, and then hydrolyzed with soda ash to obtain the target product.

Regarding safety information, you need to pay attention to the following:
1. 4-(4-Nitrophenyl) oxazole is explosive and should be stored and handled in accordance with relevant safety procedures.
2. It is a toxic substance that may cause health hazards in contact with skin, inhalation and ingestion. Wear appropriate personal protective equipment, such as gloves, protective glasses and breathing masks.
3. Avoid contact with combustibles, oxidants, strong acids and alkalis during storage and use to prevent dangerous reactions.
4. Waste disposal shall be carried out in accordance with the requirements of local regulations and environmental regulations.

Please note that due to the special nature and hazards of chemicals, corresponding work must be carried out under the supervision of suitable facilities and trained personnel.

Last Update：2024-04-10 22:29:15