4-(4-Pyridyl)bromobenzene
4-(4-Bromo-phenyl)-pyridine
CAS: 39795-60-3
Molecular Formula: C11H8BrN
4-(4-Pyridyl)bromobenzene - Names and Identifiers
4-(4-Pyridyl)bromobenzene - Physico-chemical Properties
| Molecular Formula | C11H8BrN |
| Molar Mass | 234.09 |
| Density | 1.426±0.06 g/cm3(Predicted) |
| Melting Point | 220-224°C(lit.) |
| Boling Point | 318.8±17.0 °C(Predicted) |
| Appearance | powder to crystal |
| Color | White to Yellow to Orange |
| pKa | 5.34±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
4-(4-Pyridyl)bromobenzene - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36 - Irritating to the eyes R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
4-(4-Pyridyl)bromobenzene - Introduction
4-(4-Bromo-phenyl)-pyridine is an organic compound with the chemical formula C11H8BrN. It is a pyridine derivative with a bromine substituent. The following is a description of some properties, uses, preparation and safety information about this compound:
Nature:
-Appearance: Colorless to light yellow crystal or powder
-Solubility: Soluble in organic solvents such as ether, dichloromethane and chloroform, insoluble in water
-Melting point: about 95-98 degrees Celsius
-Density: about 1.46g/cm³
-odor: with a special aromatic smell
Use:
4-(4-Bromo-phenyl)-pyridine can be used as an intermediate in organic synthesis and used to synthesize other compounds with pharmaceutical activity. It can also be used as an organic synthesis catalyst to catalyze various organic reactions. In addition, it is also used in electrochemical fields, such as electrolytic cells and electrochemical sensors.
Preparation Method:
A common preparation method is to react pyridine with bromobenzene under alkaline conditions. The specific step is that pyridine and bromobenzene are first added into a reaction flask, then an alkali solution is added, and the reaction is stirred at an appropriate temperature for a period of time to obtain a 4-(4-Bromo-phenyl)-pyridine product. After the completion of the reaction, the product with higher purity can be obtained by crystallization or column chromatography.
Safety Information:
- 4-(4-Bromo-phenyl)-pyridine irritant and may cause eye, skin and respiratory irritation. Avoid inhalation of dust or contact with skin and wear appropriate personal protective equipment.
-During operation and storage, avoid contact with oxidants and strong acids to prevent dangerous reactions.
-should be stored in a dry, well-ventilated place, away from fire and heat sources, avoid direct sunlight.
-Please read and follow the relevant safety instructions and MSDS (Chemical Safety Data Sheet) when using.
Nature:
-Appearance: Colorless to light yellow crystal or powder
-Solubility: Soluble in organic solvents such as ether, dichloromethane and chloroform, insoluble in water
-Melting point: about 95-98 degrees Celsius
-Density: about 1.46g/cm³
-odor: with a special aromatic smell
Use:
4-(4-Bromo-phenyl)-pyridine can be used as an intermediate in organic synthesis and used to synthesize other compounds with pharmaceutical activity. It can also be used as an organic synthesis catalyst to catalyze various organic reactions. In addition, it is also used in electrochemical fields, such as electrolytic cells and electrochemical sensors.
Preparation Method:
A common preparation method is to react pyridine with bromobenzene under alkaline conditions. The specific step is that pyridine and bromobenzene are first added into a reaction flask, then an alkali solution is added, and the reaction is stirred at an appropriate temperature for a period of time to obtain a 4-(4-Bromo-phenyl)-pyridine product. After the completion of the reaction, the product with higher purity can be obtained by crystallization or column chromatography.
Safety Information:
- 4-(4-Bromo-phenyl)-pyridine irritant and may cause eye, skin and respiratory irritation. Avoid inhalation of dust or contact with skin and wear appropriate personal protective equipment.
-During operation and storage, avoid contact with oxidants and strong acids to prevent dangerous reactions.
-should be stored in a dry, well-ventilated place, away from fire and heat sources, avoid direct sunlight.
-Please read and follow the relevant safety instructions and MSDS (Chemical Safety Data Sheet) when using.
Last Update：2024-04-09 20:52:54
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