4-(Aminomethyl)-1-N-Fmoc-Piperidine
9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride
CAS: 391248-14-9
Molecular Formula: C21H24N2O2
4-(Aminomethyl)-1-N-Fmoc-Piperidine - Names and Identifiers
| Name | 9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride |
| Synonyms | 4-(AMINOMETHYL)-1-N-FMOC-PIPERIDINE 4-(Aminomethyl)-1-N-Fmoc-Piperidine 1-FMoc-4-(aMinoMethyl)piperidine HCl 4-(AMinoMethyl)-1-N-FMoc-piperidine HCl 1-Fmoc-4-(Aminomethyl)Piperidine hydrochloride 4-AMINOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID 9H-FLUOREN-9-YLMETHYL ESTER 9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride (9H-fluoren-9-yl)methyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride 4-(Aminomethyl)-1-piperidinecarboxylic acid 9H-fluoren-9-ylmethyl ester hydrochloride |
| CAS | 391248-14-9 |
| InChI | InChI=1/C21H24N2O2.ClH/c22-13-15-9-11-23(12-10-15)21(24)25-14-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20;/h1-8,15,20H,9-14,22H2;1H |
4-(Aminomethyl)-1-N-Fmoc-Piperidine - Physico-chemical Properties
| Molecular Formula | C21H24N2O2 |
| Molar Mass | 336.43 |
| Boling Point | 509.2°C at 760 mmHg |
| Flash Point | 261.7°C |
| Vapor Presure | 1.74E-10mmHg at 25°C |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Irritant |
| MDL | MFCD02179398 |
4-(Aminomethyl)-1-N-Fmoc-Piperidine - Risk and Safety
| Hazard Class | IRRITANT |
4-(Aminomethyl)-1-N-Fmoc-Piperidine - Introduction
9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride is an organic compound whose chemical formula is C24H24ClNO2. It is a white solid soluble in organic solvents and is often used as a protecting group in peptide synthesis. It has the following characteristics:
1. properties: 9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride is a stable compound, not easy to decompose. It is relatively stable to light and humidity, but hydrolyzes under strong acid and alkali conditions.
2. use: it is mainly used for peptide synthesis of N-alpha-protecting group. It can protect the amino group, so that it does not react with other functional groups, so as to achieve the target peptide synthesis. After completion of the synthesis, the protecting group can be removed by appropriate conditions.
3. preparation method: 9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride can be obtained by reacting Fmoc-Cl (fluorocarbyl chloride) with 4-(aminomethyl)-piperidine under alkaline conditions. Subsequently, the hydrochloride salt form can be obtained by treatment with hydrochloric acid.
4. Safety Information: Under proper handling and storage conditions, 9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride is generally less toxic. However, as with any chemical, safe practices should be followed. Avoid direct contact with skin and eyes, and wear appropriate personal protective equipment when using. A well-ventilated laboratory environment should be maintained during processing.
1. properties: 9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride is a stable compound, not easy to decompose. It is relatively stable to light and humidity, but hydrolyzes under strong acid and alkali conditions.
2. use: it is mainly used for peptide synthesis of N-alpha-protecting group. It can protect the amino group, so that it does not react with other functional groups, so as to achieve the target peptide synthesis. After completion of the synthesis, the protecting group can be removed by appropriate conditions.
3. preparation method: 9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride can be obtained by reacting Fmoc-Cl (fluorocarbyl chloride) with 4-(aminomethyl)-piperidine under alkaline conditions. Subsequently, the hydrochloride salt form can be obtained by treatment with hydrochloric acid.
4. Safety Information: Under proper handling and storage conditions, 9H-fluoren-9-ylmethyl 4-(aminomethyl)piperidine-1-carboxylate hydrochloride is generally less toxic. However, as with any chemical, safe practices should be followed. Avoid direct contact with skin and eyes, and wear appropriate personal protective equipment when using. A well-ventilated laboratory environment should be maintained during processing.
Last Update：2024-04-10 22:29:15
