4-(Difluoromethoxy)aniline
4-(difluoromethoxy)aniline
CAS: 22236-10-8
Molecular Formula: C7H7F2NO
4-(Difluoromethoxy)aniline - Names and Identifiers
| Name | 4-(difluoromethoxy)aniline |
| Synonyms | AKOS B014415 BUTTPARK 45 3-44 AKOS BBS-00000568 TIMTEC-BB SBB003981 ART-CHEM-BB B014415 4-difluoromethoxyaniline P-DIFLUOROMETHOXYANILINE 4-(Difluoromethoxy)aniline 4-(difluoromethoxy)aniline ALPHA,ALPHA-DIFLUORO-P-ANISIDINE |
| CAS | 22236-10-8 |
| EINECS | 625-478-3 |
| InChI | InChI=1/C7H7F2NO/c8-7(9)11-6-3-1-5(10)2-4-6/h1-4,7H,10H2 |
4-(Difluoromethoxy)aniline - Physico-chemical Properties
| Molecular Formula | C7H7F2NO |
| Molar Mass | 159.13 |
| Density | 1.283 g/mL at 25 °C (lit.) |
| Boling Point | 231 °C (lit.) |
| Flash Point | >230°F |
| Vapor Presure | 0.0928mmHg at 25°C |
| Specific Gravity | 1.283 |
| BRN | 2804462 |
| pKa | 4.15±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | n20/D 1.505(lit.) |
4-(Difluoromethoxy)aniline - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 2 |
| HS Code | 29222990 |
| Hazard Note | Toxic |
| Hazard Class | 6.1 |
| Packing Group | Ⅲ |
4-(Difluoromethoxy)aniline - Introduction
4-(difluoromethoxy)aniline is an organic compound with the chemical formula C7H7F2NO. It is a colorless to light yellow solid.
Nature:
1. The molecular mass is 179.13g/mol.
2. Melting point is about 32 to 34 ° C.
3. 4-(difluoromethoxy)aniline is stable at room temperature, but may decompose at high temperature.
Use:
1. 4-(difluoromethoxy)aniline can be used as starting material or intermediate in organic synthesis.
2. It is also used in the field of medicine, can be used for the synthesis of certain drugs.
3. In the field of agriculture, it can be used as one of the ingredients of pesticides.
Method:
The preparation method of 4-(difluoromethoxy)aniline is relatively cumbersome and can be obtained through a multi-step reaction. A common method is to react 4-iodoamidoanisole with difluoromethanol, followed by reduction and amination to obtain the desired product.
Safety Information:
4-(difluoromethoxy)aniline needs to pay attention to safe operation when using it. It may cause irritation to the eyes, skin and respiratory system. If you come into contact with this substance, rinse immediately with plenty of water and seek medical attention as soon as possible. Wear appropriate protective clothing and breathing equipment during use. In addition, it also needs to be stored in a cool, dry and well-ventilated place, and away from fire and oxidants.
Nature:
1. The molecular mass is 179.13g/mol.
2. Melting point is about 32 to 34 ° C.
3. 4-(difluoromethoxy)aniline is stable at room temperature, but may decompose at high temperature.
Use:
1. 4-(difluoromethoxy)aniline can be used as starting material or intermediate in organic synthesis.
2. It is also used in the field of medicine, can be used for the synthesis of certain drugs.
3. In the field of agriculture, it can be used as one of the ingredients of pesticides.
Method:
The preparation method of 4-(difluoromethoxy)aniline is relatively cumbersome and can be obtained through a multi-step reaction. A common method is to react 4-iodoamidoanisole with difluoromethanol, followed by reduction and amination to obtain the desired product.
Safety Information:
4-(difluoromethoxy)aniline needs to pay attention to safe operation when using it. It may cause irritation to the eyes, skin and respiratory system. If you come into contact with this substance, rinse immediately with plenty of water and seek medical attention as soon as possible. Wear appropriate protective clothing and breathing equipment during use. In addition, it also needs to be stored in a cool, dry and well-ventilated place, and away from fire and oxidants.
Last Update：2024-04-09 20:52:54
