4-(Thiophen-3-yl)pyrimidin-2(1h)-imine
4-(3-Thienyl)-2-pyrimidinamine
CAS: 206564-03-6
Molecular Formula: C8H7N3S
4-(Thiophen-3-yl)pyrimidin-2(1h)-imine - Names and Identifiers
4-(Thiophen-3-yl)pyrimidin-2(1h)-imine - Physico-chemical Properties
| Molecular Formula | C8H7N3S |
| Molar Mass | 177.23 |
| Melting Point | 222～224℃ |
| Storage Condition | Room Temprature |
| Sensitive | IRRITANT |
| MDL | MFCD06659572 |
4-(Thiophen-3-yl)pyrimidin-2(1h)-imine - Introduction
4-(3-Thienyl)-2-pyrimidinamine is an organic compound with the chemical formula C8H7N3S. It is a solid, usually white or pale yellow crystalline, with a special sulfur odor. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White or light yellow crystal
-Water Soluble: Insoluble in water, soluble in organic solvents such as alcohols and ketones
-Melting point: about 180-185°C
-Molecular weight: 177.23g/mol
Use:
- 4-(3-Thienyl)-2-pyrimidinamine is an important organic synthesis intermediate, widely used in the field of medicine and pesticides
-It can be used as a precursor for the synthesis of biologically active compounds, such as anti-cancer drugs and pesticides
Preparation Method:
The synthesis method of 4-(3-Thienyl)-2-pyrimidinamine is mainly realized by the following steps:
1.3-pyridinecarboxylic acid and sulfur are heated to react to obtain 3-pyridinecarboxylic acid thiol.
2.3-pyridinecarboxylic acid thiol reacts with 3-chloro -4-methyl benzoyl chloride to generate 3-pyridinecarboxyl thiol ester.
3. Finally, 3-pyridinyl mercaptan ester and 2-aminopyrimidine are reacted under the action of hydrogen to generate 4-(3-Thienyl)-2-pyrimidinamine.
Safety Information:
- 4-(3-Thienyl)-2-pyrimidinamine requires caution. Appropriate personal protective equipment such as chemical splash resistant glasses, respirators and gloves should be worn.
-Avoid inhalation, swallowing or skin contact during use.
-It should be operated in a well-ventilated place to avoid dust and vapor.
-Please follow the correct handling and storage methods to avoid reactions with other chemicals or hazards.
-Before use or storage, please carefully read and understand the product safety data form. If necessary, dispose of waste in accordance with local regulations.
Nature:
-Appearance: White or light yellow crystal
-Water Soluble: Insoluble in water, soluble in organic solvents such as alcohols and ketones
-Melting point: about 180-185°C
-Molecular weight: 177.23g/mol
Use:
- 4-(3-Thienyl)-2-pyrimidinamine is an important organic synthesis intermediate, widely used in the field of medicine and pesticides
-It can be used as a precursor for the synthesis of biologically active compounds, such as anti-cancer drugs and pesticides
Preparation Method:
The synthesis method of 4-(3-Thienyl)-2-pyrimidinamine is mainly realized by the following steps:
1.3-pyridinecarboxylic acid and sulfur are heated to react to obtain 3-pyridinecarboxylic acid thiol.
2.3-pyridinecarboxylic acid thiol reacts with 3-chloro -4-methyl benzoyl chloride to generate 3-pyridinecarboxyl thiol ester.
3. Finally, 3-pyridinyl mercaptan ester and 2-aminopyrimidine are reacted under the action of hydrogen to generate 4-(3-Thienyl)-2-pyrimidinamine.
Safety Information:
- 4-(3-Thienyl)-2-pyrimidinamine requires caution. Appropriate personal protective equipment such as chemical splash resistant glasses, respirators and gloves should be worn.
-Avoid inhalation, swallowing or skin contact during use.
-It should be operated in a well-ventilated place to avoid dust and vapor.
-Please follow the correct handling and storage methods to avoid reactions with other chemicals or hazards.
-Before use or storage, please carefully read and understand the product safety data form. If necessary, dispose of waste in accordance with local regulations.
Last Update：2024-04-09 21:00:56
