4-(Trifluoromethyl)biphenyl

4-(Trifluoromethyl)biphenyl - Names and Identifiers

Name	4-(Trifluoromethyl)biphenyl
Synonyms	4-(Trifluoromethyl)biphenyl 4-(Trifluoromethyl)-Biphenyl 4-(TRIFLUOROMETHYL)-BIPHENYL 4-(trifluoroMethyl)-1,1'-biphenyl 1,1'-Biphenyl, 4-(trifluoromethyl)- 1-phenyl-4-(trifluoromethyl)benzene
CAS	398-36-7
InChI	InChI=1/C13H9F3/c14-13(15,16)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H

4-(Trifluoromethyl)biphenyl - Physico-chemical Properties

Molecular Formula	C13H9F3
Molar Mass	222.21
Density	1.180±0.06 g/cm3(Predicted)
Melting Point	70 °C
Boling Point	257.1±35.0 °C(Predicted)
Flash Point	95.343°C
Vapor Presure	0.024mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.505

4-(Trifluoromethyl)biphenyl - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard Class	IRRITANT

4-(Trifluoromethyl)biphenyl - Introduction

4-(Trifluoromethyl)biphenyl(4-(Trifluoromethyl)biphenyl) is an organic compound with the molecular formula C13H9F3, which is mainly formed by a trifluoromethyl group attached to an aromatic carbon in a biphenyl molecule.

The following is a brief description of the nature, use, preparation and safety information of the 4-(Trifluoromethyl)biphenyl:

Nature:
-Appearance: 4-(Trifluoromethyl)biphenyl common form is white solid crystal
-Melting point: about 95-97 ℃ (Celsius)
-Boiling point: about 339-340 ℃ (Celsius)
-Density: about 1.25g/cm³ (g/cm3)
-Solubility: Soluble in common organic solvents such as ethanol, ethers and chlorinated hydrocarbons

Use:
- 4-(Trifluoromethyl)biphenyl can be used as an important intermediate in organic synthesis, widely used in pharmaceutical, pesticide, coating and material science and other fields.
-In drug synthesis, it can be used as a synthetic intermediate for proton pump inhibitors, agonists and non-flavonoid non-steroidal anti-inflammatory drugs.

Preparation Method:
The preparation method of 4-(Trifluoromethyl)biphenyl can be used in many ways in practice. One of the common methods is to react 4-amino biphenyl with trifluoromethylmercury fluoride, and then carry out halogenation reaction and re-obtained amino protection reaction, and finally obtain the target product.

Safety Information:
- 4-(Trifluoromethyl)biphenyl is a chemical and should be handled with care to avoid contact with skin, eyes and respiratory tract.
-Wear appropriate personal protective equipment, including protective glasses, gloves and breathing apparatus, when in use.
-In the process of storage and handling, please follow the relevant safety procedures, and keep it in a dry, well-ventilated place, away from fire and flammable materials.
-In case of any accident or accidental exposure, please consult a doctor or professional immediately, and provide the safety data sheet (SDS) for reference.

Last Update：2024-04-09 02:00:45