4-(羟基亚氨基)哌啶-1-甲酸叔丁酯

4-(羟基亚氨基)哌啶-1-甲酸叔丁酯 - Names and Identifiers

Name	tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate
Synonyms	tert-Butyl 4-(hydroxyimino) N-BOC-4-(hydroxyimino)piperidine 1-Boc-4-(hydroxyimino)piperidine tert-butyl 4-(hydroxyimino)piperidin-1-carboxylate tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate TERT-BUTYL 4-(HYDROXYIMINO)PIPERIDINE-1-CARBOXYLATE 4-Hydroxyimino-piperidine-1-carboxylic acid tert-butyl ester 1-Piperidinecarboxylic acid, 4-(hydroxyiMino)-, 1,1-diMethylethyl ester
CAS	150008-24-5
InChI	InChI=1/C10H18N2O3/c1-10(2,3)15-9(13)12-6-4-8(11-14)5-7-12/h14H,4-7H2,1-3H3

4-(羟基亚氨基)哌啶-1-甲酸叔丁酯 - Physico-chemical Properties

Molecular Formula	C10H18N2O3
Molar Mass	214.26
Density	1.16g/cm³
Boling Point	333°C at 760 mmHg
Flash Point	155.2°C
Vapor Presure	2.7E-05mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.521

4-(羟基亚氨基)哌啶-1-甲酸叔丁酯 - Introduction

tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate, also known as N-tert-Butyl-4-piperidinecarboxylic acid hydroxamate, is an organic compound.

The nature of the compound is a white crystalline powder, soluble in alcohol and chloroform, insoluble in water. Its chemical formula is C12H23N3O3, the relative molecular mass is 257.33.

The main use of this compound is as a pharmaceutical intermediate. It is often used in the synthesis of antiviral and anticancer drugs in drug synthesis and has important biological activities.

The preparation of this compound can be achieved by chemical synthesis. A common synthetic method is to react 4-aminopiperidine with tert-butyryl chloride to give 4-(tert-butyrylamino) piperidine, which is then reacted with aqueous ammonia to give 4-(hydroxyimino) piperidine. This product was finally reacted with tert-butoxic acid to give the target product tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate.

Regarding safety information, this compound is an organic compound and requires attention to safe operation. It may be irritating to the skin, eyes and respiratory tract. If it comes into contact with skin, rinse immediately with plenty of water. In the process of use, should be equipped with protective glasses, gloves and protective masks, to ensure good ventilation conditions. Avoid inhaling dust or contact with substances. In addition, the compound should be stored in a dry, cool, ventilated place, away from fire and combustibles.

Last Update：2024-04-09 19:05:46