4-ACETYLBENZOFLUORIDE

Name	4-(Trifluoromethyl)acetophenone
Synonyms	4-ACETYLBENZOFLUORIDE 4-Acetylbenzotrifluoride 4-ACETYLBENZOTRIFLUORIDE p-Trifluoromethylacetophenone 2-bromo-2,2-difluoroethanamine Sodium4-trifluoromethylbenzoate 4-(TRIFLUOROMETHYL)ACETOPHENONE 4-(Trifluoromethyl)acetophenone 4'-(TRIFLUOROMETHYL)ACETOPHENONE 4[-(Trifluoromethyl)acetophenone 4-(Trifluoromethyl) acetophenone 4'-(Trifluoromethyl)acetophenone 1-(4-Trifluoromethyl-phenyl)-ethanone 1-[4-(Trifluoromethyl)phenyl]ethanone 1-[4-(trifluoromethyl)phenyl]ethanone 1-[4-(Trifluoromethyl)phenyl]ethan-1-one Ethanone, 1-[4-(trifluoromethyl)phenyl]-
CAS	709-63-7
EINECS	211-913-0
InChI	InChI=1/C2H4BrF2N/c3-2(4,5)1-6/h1,6H2

Molecular Formula	C9H7F3O
Molar Mass	188.15
Density	0.92
Melting Point	30-33°C(lit.)
Boling Point	79-80°C8mm Hg(lit.)
Flash Point	184°F
Vapor Presure	17.8mmHg at 25°C
Appearance	Low Melting Solid
Color	White to faintly yellow
BRN	1870425
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.4604

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R11 - Highly Flammable
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S16 - Keep away from sources of ignition.
WGK Germany	3
HS Code	29147090
Hazard Class	IRRITANT

NIST chemical information	information provided by: webbook.nist.gov (external link)
Introduction	4 '-trifluoromethyl acetophenone is an organic intermediate obtained by oxidation of p-trifluoromethyl ethylbenzene. Acyl groups are commonly found in organic synthesis intermediates and drug compounds. Therefore, the reaction of direct oxidation of C- H bond of aryl side chain to ketone has been widely used in chemical industry, especially in pharmaceutical industry and other fields.
Use	4 '-trifluoromethyl acetophenone can be used as a synthetic intermediate in pharmaceutical and chemical industry.
preparation	41.6g of chlorocyclohexane (0.35mol) was added dropwise to 4.65g of lithium particles (0.68mol) at -55 °c. In a suspension in 350g of THF, and an addition time of 2 hours was selected. After a conversion of chlorocyclohexane by GC of> 97% (10 hours total), a mixture of 38.3g of 4-bromotrifluorotoluene (0.170mol) and 7.0G of acetonitrile (0.170mol) was added dropwise at the same temperature. For 15 minutes. After stirring for an additional 30 minutes at -50 °c, the reaction mixture was slowly thawed to room temperature and subjected to an aqueous work-up in the usual manner. The yield of 4-trifluoromethylacetophenone after distillation was 81%.

Last Update：2024-04-09 21:11:58

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Product Name: 4-(Trifluoromethyl)acetophenone Request for quotation
CAS: 709-63-7
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228

Wechat: 13651600618
WhatsApp: +8613651600618

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