4-AMINO-6,7-DIMETHOXYQUINAZOLINE

4-AMINO-6,7-DIMETHOXYQUINAZOLINE - Names and Identifiers

Name	4-Amino-6,7-dimethoxyquinazoline
Synonyms	6,7-Dimethoxychinazolin-4-amin 6,7-Dimethoxyquinazolin-4-amine 6,7-diMethoxyquinazolin-4-aMine 6,7-Dimethoxy-4-quinazolinamine 6,7-DiMethoxy-4-quinazolinaMine 4-Amino-6,7-dimethoxyquinazoline 4-AMINO-6,7-DIMETHOXYQUINAZOLINE 4-Quinazolinamine, 6,7-dimethoxy- 4-quinazolinamine, 6,7-dimethoxy- 6,7-Dimethoxy-4-Amino-Quinzaoline 6,7-Dimethoxy-quinazolin-4-ylamine 4-Amino-6,7-Dimethoxyquinazoline New
CAS	21575-13-3
EINECS	1533716-785-6
InChI	InChI=1/C10H11N3O2/c1-14-8-3-6-7(4-9(8)15-2)12-5-13-10(6)11/h3-5H,1-2H3,(H2,11,12,13)

4-AMINO-6,7-DIMETHOXYQUINAZOLINE - Physico-chemical Properties

Molecular Formula	C10H11N3O2
Molar Mass	205.21
Density	1.28g/cm³
Boling Point	383.053°C at 760 mmHg
Flash Point	185.464°C
Vapor Presure	0mmHg at 25°C
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.642

4-AMINO-6,7-DIMETHOXYQUINAZOLINE - Introduction

4-Amino-6,7-dimethoxyquinazoline is an organic compound with the chemical formula C11H12N4O2. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
4-Amino-6,7-dimethoxyquinazoline is a white crystalline solid, stable at room temperature. It has a melting point of about 225-229°C. This compound changes color under acidic conditions.

Use:
4-Amino-6,7-dimethoxyquinazoline has important applications in the field of medicine. It is a potent tyrosine kinase inhibitor and is useful in the treatment of certain types of cancer, such as lung and stomach cancer. In addition, it can also be used as an intermediate in organic synthesis.

Method:
The preparation method of 4-Amino-6,7-dimethoxyquinazoline can be carried out by the following steps:
1.1,2-dimethoxybenzene reacts with phosgene to generate 1,2-dimethoxyphenol (also known as eugenol).
2.1,2-dimethoxyphenol reacts with N-chlorosuccinimide (N-chlorosuccinimide) to generate 1,2-dimethoxy-4-arylquinazoline.
3. Oxidation of 1,2-dimethoxy-4-arylquinazoline with tetramethyl ammonium carbonate to generate 4-Amino-6,7-dimethoxyquinazoline.

Safety Information:
4-Amino-6,7-dimethoxyquinazoline is generally relatively safe under proper use and handling conditions. However, it can cause irritation and damage to the eyes, skin and respiratory system. Therefore, appropriate protective equipment should be worn during operation to avoid direct contact. In addition, follow chemical safety practices, store and handle the compound properly, and ensure a well-ventilated work environment.

Last Update：2024-04-09 20:52:54