4-Acetyl-2,6-dichloroaniline
4-Amino-3,5-dichloroacetophenone
CAS: 37148-48-4
Molecular Formula: C8H7Cl2NO
4-Acetyl-2,6-dichloroaniline - Names and Identifiers
| Name | 4-Amino-3,5-dichloroacetophenone |
| Synonyms | 4-Acetyl-2,6-dichloroaniline 3,5-Dichloro-4-aminoacetophenone 4-Amino-3,5-dichloroacetophenone 3,5-dichloro-p-aMino acetophenone 5-AMINO-3,5-DICHLORO ACETOPHENONE 1-(4-amino-3,5-dichlorophenyl)ethanone 1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone 4''-AMINO-3'',5''-DICHLOROACETOPHENONECLENBUTEROL 1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone 4′-Amino-3′,5′-dichloroacetophenone,1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone |
| CAS | 37148-48-4 |
| EINECS | 253-368-1 |
| InChI | InChI=1/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3 |
| InChIKey | JLPKZJDZXIKSCP-UHFFFAOYSA-N |
4-Acetyl-2,6-dichloroaniline - Physico-chemical Properties
| Molecular Formula | C8H7Cl2NO |
| Molar Mass | 204.05 |
| Density | 1.2748 (rough estimate) |
| Melting Point | 162-166°C(lit.) |
| Boling Point | 351.5±42.0 °C(Predicted) |
| Flash Point | 166.4°C |
| Solubility | Insoluble in cold water, slightly soluble in hot water, soluble in ethanol, ether, benzene and other organic solvents. |
| Vapor Presure | 4.1E-05mmHg at 25°C |
| Appearance | Beige crystal |
| Color | Light Tan to Brown |
| pKa | -1.72±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.5500 (estimate) |
| MDL | MFCD00238535 |
| Physical and Chemical Properties | Beige crystals. Melting point 158-160 °c. Insoluble in cold water, slightly soluble in hot water, soluble in ethanol, ether, benzene and other organic solvents. |
| Use | It is an intermediate of the drug cretinine |
4-Acetyl-2,6-dichloroaniline - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| HS Code | 29223990 |
4-Acetyl-2,6-dichloroaniline - Reference Information
| use | 3, 5-dichloro-4-aminophenone is beige crystal and can be used as a pharmaceutical intermediate. This product is an intermediate of the synthetic antitussive and antiasthmatic drug Kechuan. It is the intermediate of the drug Kechuansu |
| Production method | Chlorination of aminoacetophenone is obtained. Add p-aminoacetophenone and acetic acid (80%) to the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, add the material at a temperature of 5 ℃, add it, immediately put it into ice water to precipitate precipitation, filter, wash with water, and the obtained crude product is recrystallized with ethanol to obtain the finished product. |
Last Update：2024-04-09 20:52:54
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