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4-Amino-1,3,5-triazin-2-one

5-Azacytosine

CAS: 931-86-2;4040-10-2

Molecular Formula: C3H4N4O

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  5. 4-Amino-1,3,5-triazin-2-one

4-Amino-1,3,5-triazin-2-one - Names and Identifiers

Name 5-Azacytosine
Synonyms 5-Azocytosine
5-AZACYTOSINE
5-Azacytosine
4-Amino-1,3,5-triazin-2-ol
4-Amino-1,3,5-triazin-2-one
4-AMINO-1,3,5-TRIAZIN-2-ONE
4-AMINO-S-TRIAZIN-2(1H)-ONE
2-AMINO-4-HYDROXY-S-TRIAZINE
1,3,5-triazin-2-ol, 4-amino-
5-triazin-2(1h)-one,4-amino-3
4-Amino-1,3,5-triazin-2(1H)-on
6-Amino-1,3,5-triazin-2(1H)-one
4-Amino-1,3,5-triazin-2(1H)-one
4-AMINO-1,3,5-TRIAZINE-2[1H]-ONE
2-Amino-4-hydroxy-1,3,5-triazine
1,3,5-triazin-2(1H)-one, 4-amino-
1,3,5-Triazin-2(1H)-one, 6-amino-
CAS 931-86-2
4040-10-2
EINECS 213-242-9
InChI InChI=1/C3H6N4O/c4-2-5-1-6-3(8)7-2/h1,3,8H,(H3,4,5,6,7)
InChIKey MFEFTTYGMZOIKO-UHFFFAOYSA-N

4-Amino-1,3,5-triazin-2-one - Physico-chemical Properties

Molecular FormulaC3H4N4O
Molar Mass112.09
Density1.86
Melting Point>300 °C (lit.)
Boling Point209.98°C (rough estimate)
Solubility Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated)
AppearanceCrystallization
ColorWhite to Off-White
BRN116378
pKa7.61±0.10(Predicted)
Storage ConditionKeep in dark place,Inert atmosphere,2-8°C
Refractive Index1.8010 (estimate)
MDLMFCD00006033

4-Amino-1,3,5-triazin-2-one - Risk and Safety

Risk CodesR20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSXZ2854300
HS Code29336990

4-Amino-1,3,5-triazin-2-one - Reference Information

Application 5-azacytosine, also known as 4-amino -1,3, 5-triazin-2-one is the basic raw material for the synthesis of 5-azacytidine drugs. As a synthetic pyrimidine base, 5-azacytidine can be combined with ribose to form 5-azacytidine, it can infiltrate the tumor nucleic acid as a pseudo metabolite, and interfere with the physiological function of tumor cells to produce anti-tumor effect.
currently developed therapeutic drugs using 5-azacytidine as raw materials include 5-azacytidine, commercial name Vidaza. And 5-aza-2 '-deoxycytidine, trade name Decitabine. This class of drugs has been demonstrated clinically for myelodysplastic syndromes, myeloid leukemia, sickle cell anemia, and in some solid tumors.
preparation put 140 of formic acid into the reaction kettle, turn on the stirring, put 25 of dicyandiamide, the reaction temperature will rise gradually by itself, and the temperature should be controlled below 60 ℃. After the reaction temperature no longer rises, the remaining 75kg of dicyandiamide will be added into the reaction kettle in 4-5 hours, the reaction was stirred at 50-60 ° C. For 4 hours, and then the temperature control measures were stopped. The reaction temperature was slowly increased, and the temperature was raised to 100-110 ° C. For 1 hour.

120 of acetic anhydride is dropped into the reaction kettle, and the temperature is maintained at 100~110 ° C. During The dropping process, and after the dropping is completed, the mixture is stirred at this temperature for 45 minutes; 100 of acetic anhydride was added dropwise again, and after the dropwise addition, the temperature was raised to reflux, and the reaction was maintained at reflux for 2 hours.

after the reflux was completed, the temperature was lowered to 60-70 ° C. By stirring, 120 of ethanol was added, and the temperature was further lowered to room temperature. Filter, filter cake into the reaction kettle, add 480 of ethyl acetate and 96kg of ethanol, heated to 65~75 ℃, stirred for 1 hour after the hot filter, filter cake drying, 74kg of 5-azacytosine was obtained, the HPLC purity was 98.9%, the content of impurity 1 was 0.34%, and the content of impurity 2 was 0.06%.
Last Update：2024-04-09 02:00:12
4-Amino-1,3,5-triazin-2-one
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Nantong Reform Petro-Chemical CO., LTD.
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Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: 5-Azacytosine Request for quotation
CAS: 931-86-2
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: 5-Azacytosine Request for quotation
CAS: 931-86-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Cytosine Impurity 1 Visit Supplier Webpage Request for quotation
CAS: 931-86-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: 5-Azacytosine Request for quotation
CAS: 931-86-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: 5-Azacytosine Visit Supplier Webpage Request for quotation
CAS: 931-86-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Worldyang Chemical Co.,Ltd.
Multiple Specifications
Product Name: 5-Azacytosine Request for quotation
CAS: 931-86-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Zouping Mingxing Chemical Co., Ltd.
Product Name: 5-Azacytosine Request for quotation
CAS: 931-86-2
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987 Click to send a QQ message
Wechat: 13605431940
WhatsApp: 13605431940
Suzhou Janlon Biopharma Co Ltd
Product Name: 5-Azacytosine Request for quotation
CAS: 931-86-2
Tel: 0512-67909115
Email:
Mobile: 18662510535
QQ: 99938187 Click to send a QQ messageSend QQ message
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4-Amino-1,3,5-triazin-2-one
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