4-Amino-3-bromo-2-hydroxypyridine

4-Amino-3-bromo-2-hydroxypyridine - Names and Identifiers

Name	4-Amino-3-bromo-2-hydroxypyridine
Synonyms	4-Amino-3-bromopyridin-2-ol 4-amino-3-bromopyridin-2(1H)-one 4-amino-3-bromo-1H-pyridin-2-one 4-Amino-3-bromo-2-hydroxypyridine 2(1H)-Pyridinone, 4-amino-3-bromo-
CAS	107842-74-0
InChI	InChI=1/C5H5BrN2O/c6-4-3(7)1-2-8-5(4)9/h1-2H,(H3,7,8,9)

4-Amino-3-bromo-2-hydroxypyridine - Physico-chemical Properties

Molecular Formula	C5H5BrN2O
Molar Mass	189.01
Density	1.826±0.06 g/cm3(Predicted)
Melting Point	255-258 °C
Boling Point	284.7±40.0 °C(Predicted)
Flash Point	126°C
Vapor Presure	0.00293mmHg at 25°C
pKa	10.00±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.635

4-Amino-3-bromo-2-hydroxypyridine - Introduction

4-Amino -3-bromopyridin-2-ol is an organic compound with the chemical formula C≡H≡BrN₂ O. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: 4-Amino-3-bromopyridin-2-ol is a white crystalline solid.
-Solubility: It is insoluble in water, but easily soluble in organic solvents such as ethanol and chloroform.
-Melting point: Its melting point is about 172-176°C.
-Flammability: 4-Amino-3-bromopyridin-2-ol is flammable at high temperatures.

Use:
4-amino -3-bromopyridin-2-ol has a wide range of uses in chemical synthesis:
-Pharmaceutical: It can be used to synthesize some drug intermediates or drug active structures.
-Pesticide: It can be used as a pesticide intermediate or a raw material for pesticide active ingredients.
-Others: It can also be used as a catalyst in organic synthesis reactions, the synthesis of transition metal coordination compounds, etc.

Preparation Method:
The synthesis method of 4-amino-3-bromopyridin-2-ol can be carried out by the following steps:
1. 3-bromopyridin-2-ol is reacted with acetone under alkaline conditions to obtain 3-bromopyridin-2-one.
2.3-bromopyridin-2-one is reacted with ammonia water to generate 4-amino -3-bromopyridin-2-one.
3. Finally, 4-amino -3-bromopyridin-2-one is reacted with a base to generate 4-amino -3-bromopyridin-2-ol.

Safety Information:

Last Update：2024-04-09 21:00:56