4-Amino-3-fluoropyridine
4-Amino-3-Fluoropyridine
CAS: 2247-88-3
Molecular Formula: C5H5FN2
4-Amino-3-fluoropyridine - Names and Identifiers
| Name | 4-Amino-3-Fluoropyridine |
| Synonyms | 4-Amin fluoropyridin-4-amine 4-AMINO-3-FLUOROPYRINE 3-Fluoro-4-pyridinamine 3-FLUOROPYRIDIN-4-AMINE 3-Fluoropyridin-4-amine 3-FLUORO-4-AMINOPYRIDINE 4-AMINO-3-FLUOROPYRIDINE 4-Amino-3-Fluoropyridine |
| CAS | 2247-88-3 |
| InChI | InChI=1/C5H5FN2/c6-4-3-8-2-1-5(4)7/h1-3H,(H2,7,8) |
| InChIKey | UFIKBUVVVGSMGW-UHFFFAOYSA-N |
4-Amino-3-fluoropyridine - Physico-chemical Properties
| Molecular Formula | C5H5FN2 |
| Molar Mass | 112.11 |
| Density | 1.257±0.06 g/cm3(Predicted) |
| Melting Point | 71-79 °C |
| Boling Point | 217.1±20.0 °C(Predicted) |
| Flash Point | 85.1°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.135mmHg at 25°C |
| Appearance | Crystallization |
| Color | White to Light yellow to Light orange |
| pKa | 7.19±0.12(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.554 |
| MDL | MFCD00234072 |
4-Amino-3-fluoropyridine - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | nwg |
| HS Code | 29333990 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
4-Amino-3-fluoropyridine - Introduction
4-Amino-3-Fluoropyridine(4-Amino-3-Fluoropyridine) is an organic compound with the chemical formula C5H4FN2. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
- 4-Amino-3-Fluoropyridine is a white crystalline solid with a characteristic aroma of pyridine.
-It has a certain solubility, soluble in many organic solvents, such as alcohols, ethers and ketones.
-It is a compound with a melting point, usually melting in the range of 140-145°C.
-Relatively stable in air, but can burn under high temperature or flame.
Use:
- 4-Amino-3-Fluoropyridine is commonly used as an intermediate in organic synthesis. It can participate in various reactions, such as nucleophilic substitution, reduction, etc.
-It is widely used in the field of medicine as an important raw material for drug synthesis. It plays an important role in the synthesis of a variety of drugs, biomarkers and compound library screening.
Method:
The preparation of-4-Amino-3-Fluoropyridine is usually completed by the fluorination reaction of pyridine and the subsequent amination reaction. First, pyridine is reacted with hydrogen fluoride or sodium fluoride, and fluorination reaction occurs by the action of fluoride ions to obtain 3-fluoropyridine. The 3-fluoropyridine is then reduced to 4-amino-3-fluoropyridine by a reducing agent (e. G., sulfite).
Safety Information:
- 4-Amino-3-Fluoropyridine is an organic compound, which requires safety measures when using and storing.
-It may be irritating to the skin, eyes and respiratory tract, so wear appropriate personal protective equipment such as protective gloves, protective glasses and protective masks during operation.
-Avoid inhaling its powder or solution, avoid direct contact with skin and eyes.
-should be stored away from fire and oxidant, stored in a dry, cool place.
-In case of ingestion or accident, seek medical attention immediately and provide detailed information about the compound.
Nature:
- 4-Amino-3-Fluoropyridine is a white crystalline solid with a characteristic aroma of pyridine.
-It has a certain solubility, soluble in many organic solvents, such as alcohols, ethers and ketones.
-It is a compound with a melting point, usually melting in the range of 140-145°C.
-Relatively stable in air, but can burn under high temperature or flame.
Use:
- 4-Amino-3-Fluoropyridine is commonly used as an intermediate in organic synthesis. It can participate in various reactions, such as nucleophilic substitution, reduction, etc.
-It is widely used in the field of medicine as an important raw material for drug synthesis. It plays an important role in the synthesis of a variety of drugs, biomarkers and compound library screening.
Method:
The preparation of-4-Amino-3-Fluoropyridine is usually completed by the fluorination reaction of pyridine and the subsequent amination reaction. First, pyridine is reacted with hydrogen fluoride or sodium fluoride, and fluorination reaction occurs by the action of fluoride ions to obtain 3-fluoropyridine. The 3-fluoropyridine is then reduced to 4-amino-3-fluoropyridine by a reducing agent (e. G., sulfite).
Safety Information:
- 4-Amino-3-Fluoropyridine is an organic compound, which requires safety measures when using and storing.
-It may be irritating to the skin, eyes and respiratory tract, so wear appropriate personal protective equipment such as protective gloves, protective glasses and protective masks during operation.
-Avoid inhaling its powder or solution, avoid direct contact with skin and eyes.
-should be stored away from fire and oxidant, stored in a dry, cool place.
-In case of ingestion or accident, seek medical attention immediately and provide detailed information about the compound.
Last Update：2024-04-09 21:01:54
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