4-Amino-3-trifluoromethylbenzoicacid

4-Amino-3-trifluoromethylbenzoicacid - Names and Identifiers

Name	4-amino-3-(trifluoromethyl)benzoic acid
Synonyms	4-Amino-3-trifluoromethylbenzoicacid 3-Trifluoromethyl-4-AminoBenzoicAcid 4-Amino-5-trifluoromethylbenzoic Acid 4-AMino-α,α,α-trifluoro-M-toluic Acid 4-Amino-3- trifluoromethylbenzioc acid 4-amino-3-(trifluoromethyl)benzoic acid Benzoic acid, 4-amino-3-(trifluoromethyl)- 4-Amino-3-(Trifluoromethyl)Benzoic Acid 3-Trifluoromethyl-4-Aminobenzoic Acid
CAS	400-76-0
EINECS	630-042-0
InChI	InChI=1/2C8H6F3NO2/c29-8(10,11)5-3-4(7(13)14)1-2-6(5)12/h21-3H,12H2,(H,13,14)

4-Amino-3-trifluoromethylbenzoicacid - Physico-chemical Properties

Molecular Formula	C8H6F3NO2
Molar Mass	205.13
Density	1.489
Melting Point	204-206°C
Boling Point	319.1±42.0 °C(Predicted)
Solubility	DMSO, Methaniol
Appearance	Solid
Color	Off-White to Pale Yellow
pKa	4.43±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Sensitive	Air Sensitive

4-Amino-3-trifluoromethylbenzoicacid - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

4-Amino-3-trifluoromethylbenzoicacid - Introduction

4-amino-3-(trifluoromethyl)benzoic acid(4-amino-3-(trifluoromethyl)benzoic acid) is an organic compound with the chemical formula C8H6F3NO2. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless crystalline solid
-Molecular weight: 209.1g/mol
-Melting point: 144-148 degrees Celsius
-Solubility: Poor solubility in water, easy to dissolve in organic solvents such as ethanol and ether

Use:
- 4-amino-3-(trifluoromethyl)benzoic acid is used as an intermediate for the synthesis of certain drugs in the pharmaceutical field.
-It can also be used as a unit reaction reagent in organic synthesis to construct organic molecules with specific structures and functions.

Preparation Method:
The preparation of -4-amino-3-(trifluoromethyl)benzoic acid can be achieved by the reaction between trifluoromethanesulfonic acid trifluoromethyl ester and 4-aminobenzoic acid.
-First, under appropriate solvent conditions, trifluoromethyl trifluoromethanesulfonate is added to 4-aminobenzoic acid, and the reaction proceeds.
-After the reaction is over, the product is obtained, which can be crystallized and purified to obtain pure 4-amino-3-(trifluoromethyl)benzoic acid.

Safety Information:
- 4-amino-3-(trifluoromethyl)benzoic acid is considered to be a relatively safe compound under general conditions, but certain safe operation measures are still needed.
-During use, avoid contact with skin and eyes, and wear protective gloves and goggles if necessary.
-Make sure to operate in a well-ventilated place and avoid inhaling its dust or vapor.
-Seek immediate medical help if ingested or inhaled.

Last Update：2024-04-09 21:01:54