4-Amino-5-pyrimidinecarboxamide

4-Amino-5-pyrimidinecarboxamide - Names and Identifiers

Name	4-aminopyrimidine-5-carboxamide
Synonyms	4-aminopyrimidine-5-carboxamide 4-Amino-5-pyrimidinecarboxamide 5-Pyrimidinecarboxamide, 4-amino- 5-pyrimidinecarboxamide, 4-amino- 5-Pyrimidinecarboxamide, 4-amino- (6CI,7CI,8CI,9CI)
CAS	4786-51-0
InChI	InChI=1/C5H6N4O/c6-4-3(5(7)10)1-8-2-9-4/h1-2H,(H2,7,10)(H2,6,8,9)

4-Amino-5-pyrimidinecarboxamide - Physico-chemical Properties

Molecular Formula	C5H6N4O
Molar Mass	138.13
Density	1.426g/cm³
Boling Point	366.3°C at 760 mmHg
Flash Point	175.3°C
Vapor Presure	1.48E-05mmHg at 25°C
Storage Condition	2-8°C(protect from light)
Refractive Index	1.656

4-Amino-5-pyrimidinecarboxamide - Risk and Safety

Risk Codes	20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes.
HS Code	29335990

4-Amino-5-pyrimidinecarboxamide - Introduction

It is an organic compound with the chemical formula C5H5N3O, also known as 4-APC. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: White or yellowish crystalline solid.
-Solubility: Soluble in water, slightly soluble in ethanol and chloroform.
-Melting point: Its melting point is 230-232°C.
-Stability: Stable at room temperature, but may decompose at high temperature.

Use:
-As a drug intermediate: It is an important intermediate that can be used to synthesize various drugs, especially compounds with antiviral and anticancer activities.
-Biological research: It is also used as a compound in biological research to synthesize biological molecules such as DNA and RNA.

Preparation Method:
There are two main preparation methods:
-Synthesis method 1: By reacting pyrimidine -5-formamide with an amination reagent, such as ammonia or ethylenediamine, the target product is generated.
-Synthesis method II: It is obtained by reduction reaction of pyrimidine -5-formamide and nitropyrimidine.

Safety Information:
-It is generally considered to be less toxic to humans, but it still needs to be used and stored correctly, avoiding inhalation, swallowing or contact with skin.
-Follow relevant laboratory safety regulations and use appropriate protective equipment, such as lab gloves, safety glasses and protective clothing.
-If the compound is accidentally ingested or inhaled, seek medical attention immediately.

Last Update：2024-04-09 02:00:46