4-BENZYLAMINO-1-BOC-PIPERIDINE

4-BENZYLAMINO-1-BOC-PIPERIDINE - Names and Identifiers

Name	tert-Butyl 4-(benzylamino)piperidine-1-carboxylate
Synonyms	1-BOC-4-BENZYLAMINOPIPERIDIN 4-BENZYLAMINO-1-BOC-PIPERIDINE 1-BOC-4-BENZYLAMINO-PIPERIDINE 1-N-BOC-4-(BENZYLAMINO)PIPERIDINE 4-BENZYLAMINOPIPERIDINE, 1-BOC PROTECTED 4-(Benzylamino)piperidine, N1-BOC protected tert-Butyl 4-(benzylamino)piperidine-1-carboxylate TERT-BUTYL 4-(BENZYLAMINO)PIPERIDINE-1-CARBOXYLATE 4-BENZYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-piperidinecarboxylic acid, 4-[(phenylmethyl)amino]-, 1,1-dimethylethyl ester
CAS	206273-87-2
InChI	InChI=1/C17H26N2O2/c1-17(2,3)21-16(20)19-11-9-15(10-12-19)18-13-14-7-5-4-6-8-14/h4-8,15,18H,9-13H2,1-3H3

4-BENZYLAMINO-1-BOC-PIPERIDINE - Physico-chemical Properties

Molecular Formula	C17H26N2O2
Molar Mass	290.4
Density	1.076g/cm³
Boling Point	398.115°C at 760 mmHg
Flash Point	194.573°C
Vapor Presure	0mmHg at 25°C
Storage Condition	2-8°C(protect from light)
Refractive Index	1.542

4-BENZYLAMINO-1-BOC-PIPERIDINE - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
HS Code	29333220
Hazard Note	Irritant

4-BENZYLAMINO-1-BOC-PIPERIDINE - Introduction

tert-Butyl 4-(benzylamino)piperidine-1-carboxylate is an organic compound with the chemical formula C16H22N2O2. It is a white solid, soluble in organic solvents such as dimethyl sulfoxide and chloroform, but insoluble in water.

tert-Butyl 4-(benzylamino)piperidine-1-carboxylate is commonly used in organic synthesis as a protecting group for piperidine. Once the amino group of piperidine is protected, its reactivity and stability are enhanced. Thus, in the synthesis of complex molecules, the tert-Butyl 4-(benzylamino)piperidine-1-carboxylate can be used to protect the amino group of the piperidine and then remove the protecting group when desired.

The method for preparing tert-Butyl 4-(benzylamino)piperidine-1-carboxylate is usually to react 4-benzylaminopiperidine with di-tert-butyl carbonate (Boc2O). As the reaction proceeds, a base such as pyridine may be added to facilitate the reaction. After completion of the reaction, the product can be obtained by crystallization or chromatographic purification.

For safety information, tert-Butyl 4-(benzylamino)piperidine-1-carboxylate may cause irritation to eyes, skin and mucous membranes. During use, it is recommended to wear personal protective equipment such as gloves, goggles and protective clothing. At the same time, it should be stored in a dry, well-ventilated place to avoid contact with oxidants and fire sources. If exposed, rinse immediately with water and seek medical help.

In General, tert-Butyl 4-(benzylamino)piperidine-1-carboxylate is a compound commonly used in organic synthesis. It has the effect of protecting the piperidinyl amino group and the preparation method is relatively simple. But in use should pay attention to safety measures, and properly stored.

Last Update：2024-04-10 22:29:15