4-Bromo-2,3-Difluoroanisole

4-Bromo-2,3-Difluoroanisole - Names and Identifiers

Name	4-Bromo-2,3-Difluoroanisole
Synonyms	2,3-Difluoro-4-bromoanisole 4-Bromo-2,3-Difluoroanisole 4-Bromo-2,3-difluoroanisole 1-Bromo-2,3-difluoro-4-methoxybenzene 1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE 4-Bromo-2,3-difluorophenyl methyl ether Benzene, 1-bromo-2,3-difluoro-4-methoxy- benzene, 1-bromo-2,3-difluoro-4-methoxy-
CAS	406482-22-2
InChI	InChI=1/C7H5BrF2O/c1-11-5-3-2-4(8)6(9)7(5)10/h2-3H,1H3

4-Bromo-2,3-Difluoroanisole - Physico-chemical Properties

Molecular Formula	C7H5BrF2O
Molar Mass	223.01
Density	1.615
Boling Point	203.2±35.0 °C(Predicted)
Flash Point	91.1°C
Vapor Presure	0.4mmHg at 25°C
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.5

4-Bromo-2,3-Difluoroanisole - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

4-Bromo-2,3-Difluoroanisole - Introduction

4-Bromo-2,3-Difluoroanisole is an organic compound with the formula BrC6H3(F)2OCH3. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: 4-Bromo-2,3-Difluoroanisole is a colorless to slightly yellow liquid.
-Solubility: It can be dissolved in common organic solvents such as ethanol, ether and dimethylformamide.

Use:
- 4-Bromo-2,3-Difluoroanisole is commonly used in arylation reactions in organic synthesis and can be used as a derivative of aromatic ethers.
-It can also be used as a pharmaceutical and pesticide intermediate for the synthesis of other organic compounds.

Preparation Method:
- 4-Bromo-2,3-Difluoroanisole can be synthesized by bromination and fluorination of p-hydroxybenzoic acid.
-Synthesis steps:
1. p-hydroxybenzoic acid is reacted with bromine and a fluorinating agent to obtain 4-bromo-2, 3-difluorobenzoic acid.
2. The obtained 4-bromo-2, 3-difluorobenzoic acid is reacted with methanol to generate 4-Bromo-2,3-Difluoroanisole by condensation reaction.

Safety Information:
- 4-Bromo-2,3-Difluoroanisole may be irritating to humans and care should be taken to prevent contact with skin, eyes and respiratory tract.
-Wear appropriate personal protective equipment, such as lab gloves and masks, during use and handling.
-The compound should be used in a well-ventilated place to avoid inhaling its vapors.
-Seek medical help if ingested or inhaled.

Last Update：2024-04-09 15:17:57