4-Bromo-2,6-dichloroaniline

4-Bromo-2,6-dichloroaniline - Names and Identifiers

Name	4-Bromo-2,6-dichloroaniline
Synonyms	4-Bromo-2,6-dichloroaniline 2,6-DICHLORO-4-BROMOANILINE 4-BROMO-2,6-DICHLOROANILINE 4-Bromo-2,4,-dichloroaniline 4-BROMO-2,6-DICHLORO-BENZENAMINE 4-Bromo-2,6-dichloro-1-benzenamin (4-BROMO-2,6-DICHLOROPHENYL)AMINE 4-Bromo-2,6-dichloro-1-benzenamine (4-Bromo-2,6-dichlorophenyl)amine, 2,6-Dichloro-4-bromoaniline, 4-Bromo-2,6-dichloro-benzenamine
CAS	697-88-1
EINECS	211-809-5
InChI	InChI=1/C6H4BrCl2N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2

4-Bromo-2,6-dichloroaniline - Physico-chemical Properties

Molecular Formula	C6H4BrCl2N
Molar Mass	240.91
Density	1.827±0.06 g/cm3(Predicted)
Melting Point	83-87 °C
Boling Point	256.5±35.0 °C(Predicted)
Flash Point	108.9°C
Vapor Presure	0.0153mmHg at 25°C
Appearance	Crystalline powder
BRN	2089687
pKa	0.00±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.648
MDL	MFCD00025162

4-Bromo-2,6-dichloroaniline - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust.
WGK Germany	3
HS Code	29214200
Hazard Note	Irritant/Harmful

4-Bromo-2,6-dichloroaniline - Reference Information

Application

4-bromo -2, 6-dichloroaniline is used to synthesize dipyard, Liguron, mikazolin and azo dyes, etc. Reagents for preparing 4-alkyl-1-phenylpyrazole and 4-alkyl-1-phenyltrioxo-octane derivatives of GABA receptor antagonist insecticides.

Preparation

Using 2,6-dichloroaniline as raw material, NBS as brominating reagent, BPO as initiator, a free radical bromination reaction occurs in carbon tetrachloride solution to obtain 4-bromo-2, 6-dichloroaniline. 2,6-dichloroaniline, 30mL carbon tetrachloride, N-bromosuccinimide and benzoyl peroxide were added to the reaction system, reacted at 60 ℃ for 7h, and the reaction was monitored by TLC. After the reaction was completed, the solvent was distilled under reduced pressure. The obtained crude product was purified by column chromatography (V petroleum ether: V ethyl acetate = 10: 1) to obtain light yellow solid 1.20g.

Last Update：2024-04-09 20:52:54