4-Bromo-3-fluorobenzaldehyde
4-Bromo-3-fluorobenzaldehyde
CAS: 133059-43-5
Molecular Formula: C7H4BrFO
4-Bromo-3-fluorobenzaldehyde - Names and Identifiers
| Name | 4-Bromo-3-fluorobenzaldehyde |
| Synonyms | 4-Bromo-3-fluorobenzaldehyde 3-Fluoro-4-bromobenzaldehyde 4-BROMO-3-FLUOROBENZALDEHYDE Benzaldehyde, 4-broMo-3-fluoro- 4 - broMine - 3 - fluoro benzaldehyde |
| CAS | 133059-43-5 |
| InChI | InChI=1/C7H4BrFO/c8-6-2-1-5(4-10)3-7(6)9/h1-4H |
| InChIKey | SWHUROFMIMHWKS-UHFFFAOYSA-N |
4-Bromo-3-fluorobenzaldehyde - Physico-chemical Properties
| Molecular Formula | C7H4BrFO |
| Molar Mass | 203.01 |
| Density | 1.670±0.06 g/cm3(Predicted) |
| Melting Point | 55-59 °C |
| Boling Point | 240.2±25.0 °C(Predicted) |
| Flash Point | 99.1°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.0384mmHg at 25°C |
| Appearance | White to bright yellow crystals |
| Color | White to Light yellow |
| Storage Condition | 2-8°C |
| Refractive Index | 1.584 |
| MDL | MFCD03095000 |
4-Bromo-3-fluorobenzaldehyde - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| HS Code | 29130000 |
| Hazard Note | Irritant |
4-Bromo-3-fluorobenzaldehyde - Introduction
4-Bromo-3-fluorobenzaldehyde is an organic compound with the chemical formula C7H4BrFO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance is white crystal or crystalline powder.
-Solid at room temperature, soluble in organic solvents such as ethanol, methanol and dichloromethane.
-Melting point is about 58-60°C.
-It has a strong odor.
Use:
-4-bromo-3-fluorobenzaldehyde is mainly used in organic synthesis reactions and can be used as an intermediate for the synthesis of other organic compounds.
-It is widely used in the fields of pesticides, drugs and dyes.
Preparation Method:
4-Bromo-3-fluorobenzaldehyde is usually prepared by the following reaction:
1. first, p-bromo chlorobenzene or p-bromo nitrobenzene is converted into p-bromo fluorobenzene or p-bromo nitrofluorobenzene by hydrogen fluoride.
2. p-bromofluorobenzene or p-bromo-nitrofluorobenzene is reacted with sodium cyanide in dichloromethane to obtain p-bromo -3-fluorobenzonitrile.
3. Finally, p-bromo-3-fluorobenzonitrile is reacted with an alkaline solution (such as sodium carbonate solution) and sodium hydroxide to prepare 4-bromo-3-fluorobenzaldehyde.
Safety Information:
-4-Bromo-3-fluorobenzaldehyde should be used in accordance with chemical safety practices.
-It is an organic compound with certain toxicity. Please avoid direct contact with skin and eyes.
-Wear personal protective equipment such as protective gloves, safety glasses and protective clothing when handling the compound.
-For the use and storage of this compound, it needs to be carried out in a well-ventilated place and kept away from fire and flammable materials.
-For accidental inhalation or ingestion, seek medical help immediately and provide the packaging or label to your doctor for reference.
Nature:
-Appearance is white crystal or crystalline powder.
-Solid at room temperature, soluble in organic solvents such as ethanol, methanol and dichloromethane.
-Melting point is about 58-60°C.
-It has a strong odor.
Use:
-4-bromo-3-fluorobenzaldehyde is mainly used in organic synthesis reactions and can be used as an intermediate for the synthesis of other organic compounds.
-It is widely used in the fields of pesticides, drugs and dyes.
Preparation Method:
4-Bromo-3-fluorobenzaldehyde is usually prepared by the following reaction:
1. first, p-bromo chlorobenzene or p-bromo nitrobenzene is converted into p-bromo fluorobenzene or p-bromo nitrofluorobenzene by hydrogen fluoride.
2. p-bromofluorobenzene or p-bromo-nitrofluorobenzene is reacted with sodium cyanide in dichloromethane to obtain p-bromo -3-fluorobenzonitrile.
3. Finally, p-bromo-3-fluorobenzonitrile is reacted with an alkaline solution (such as sodium carbonate solution) and sodium hydroxide to prepare 4-bromo-3-fluorobenzaldehyde.
Safety Information:
-4-Bromo-3-fluorobenzaldehyde should be used in accordance with chemical safety practices.
-It is an organic compound with certain toxicity. Please avoid direct contact with skin and eyes.
-Wear personal protective equipment such as protective gloves, safety glasses and protective clothing when handling the compound.
-For the use and storage of this compound, it needs to be carried out in a well-ventilated place and kept away from fire and flammable materials.
-For accidental inhalation or ingestion, seek medical help immediately and provide the packaging or label to your doctor for reference.
Last Update：2024-04-09 21:00:56
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CAS: 133059-43-5
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