4-Bromo-3-oxo-N-phenylbutanamide
4-Bromo-3-oxo-N-phenylbutanamide
CAS: 1205-74-9
Molecular Formula: C10H10BrNO2
4-Bromo-3-oxo-N-phenylbutanamide - Names and Identifiers
| Name | 4-Bromo-3-oxo-N-phenylbutanamide |
| Synonyms | 4-BROMO-3-OXOBUTYRANILIDE Acetoacetanilide, 4-bromo- 4-Bromo-3-oxo-N-phenylbutanamide Butanamide, 4-bromo-3-oxo-N-phenyl- |
| CAS | 1205-74-9 |
| InChI | InChI=1/C10H10BrNO2/c11-7-9(13)6-10(14)12-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,12,14) |
4-Bromo-3-oxo-N-phenylbutanamide - Physico-chemical Properties
| Molecular Formula | C10H10BrNO2 |
| Molar Mass | 256.1 |
| Density | 1.544g/cm3 |
| Boling Point | 437.3°C at 760 mmHg |
| Flash Point | 218.3°C |
| Vapor Presure | 7.55E-08mmHg at 25°C |
| Refractive Index | 1.61 |
4-Bromo-3-oxo-N-phenylbutanamide - Introduction
4-Bromo-3-oxo-N-phenylbutanamide is an organic compound whose structural formula is C10H11BrNO2.
Nature:
The compound is a colorless or slightly yellow crystal with a special ammonia fragrance. It has good solubility at room temperature, soluble in alcohols, ethers and chloroform and other organic solvents.
Use:
4-Bromo-3-oxo-N-phenylbutanamide is a commonly used compound synthesis intermediate. It is widely used in pharmaceutical synthesis, organic synthesis and pesticide synthesis and other fields. For example, it can be used in the synthesis of indole anticancer drugs, organic pigments, dyes and photosensitive materials.
Preparation Method:
4-Bromo-3-oxo-N-phenylbutyramide can be obtained by the reaction of phenylacetic acid and sodium bromoformate. The specific synthesis method is as follows:
1. In absolute ethanol, phenylacetic acid and sodium bromoformate are heated and stirred to obtain sodium benzyl bromoformate.
2. reacting sodium benzyl bromide with butyryl chloride to generate 4-bromobenzyl butyryl chloride.
3. Finally, 4-bromobenzylbutyryl chloride was reacted with hydrogen peroxide to prepare the target product.
Safety Information:
4-bromo-3-oxo-N-phenylbutanamide is an organic compound, which should be operated safely when used. It is irritating to the eyes, skin and respiratory tract and may cause irritation or allergic reactions. Wear suitable protective gloves, glasses and respiratory protective equipment when in use. Avoid contact with fire and high temperature substances. In storage, should be stored in a cool, dry, ventilated place, away from fire and flammable materials.
Nature:
The compound is a colorless or slightly yellow crystal with a special ammonia fragrance. It has good solubility at room temperature, soluble in alcohols, ethers and chloroform and other organic solvents.
Use:
4-Bromo-3-oxo-N-phenylbutanamide is a commonly used compound synthesis intermediate. It is widely used in pharmaceutical synthesis, organic synthesis and pesticide synthesis and other fields. For example, it can be used in the synthesis of indole anticancer drugs, organic pigments, dyes and photosensitive materials.
Preparation Method:
4-Bromo-3-oxo-N-phenylbutyramide can be obtained by the reaction of phenylacetic acid and sodium bromoformate. The specific synthesis method is as follows:
1. In absolute ethanol, phenylacetic acid and sodium bromoformate are heated and stirred to obtain sodium benzyl bromoformate.
2. reacting sodium benzyl bromide with butyryl chloride to generate 4-bromobenzyl butyryl chloride.
3. Finally, 4-bromobenzylbutyryl chloride was reacted with hydrogen peroxide to prepare the target product.
Safety Information:
4-bromo-3-oxo-N-phenylbutanamide is an organic compound, which should be operated safely when used. It is irritating to the eyes, skin and respiratory tract and may cause irritation or allergic reactions. Wear suitable protective gloves, glasses and respiratory protective equipment when in use. Avoid contact with fire and high temperature substances. In storage, should be stored in a cool, dry, ventilated place, away from fire and flammable materials.
Last Update：2024-04-09 21:00:56
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Spot supply
Product Name: Prilocaine Impurity 40 Visit Supplier Webpage Request for quotationCAS: 1205-74-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
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