4-Bromoindolin-2-one
4-Bromo-2-oxyindole
CAS: 99365-48-7
Molecular Formula: C8H6BrNO
4-Bromoindolin-2-one - Names and Identifiers
| Name | 4-Bromo-2-oxyindole |
| Synonyms | 4-BROMOOXINDOLE 4-bromooxindole 4-Bromo-2-oxindole 4-Bromo-2-oxyindole 4-BROMO-2-OXYINDOLE 4-Bromoindolin-2-one 4-BroMo-1,3-dihydro-indol-2-one 4-Bromo-2,3-dihydro-1H-indol-2-one 4-bromo-1,3-dihydro-2H-indol-2-one |
| CAS | 99365-48-7 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C8H6BrNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11) |
4-Bromoindolin-2-one - Physico-chemical Properties
| Molecular Formula | C8H6BrNO |
| Molar Mass | 212.04 |
| Density | 1.666±0.06 g/cm3(Predicted) |
| Melting Point | 202-208 |
| Boling Point | 358.2±42.0 °C(Predicted) |
| Flash Point | 170.4°C |
| Vapor Presure | 2.6E-05mmHg at 25°C |
| Appearance | Crystalline powder |
| pKa | 13.24±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.625 |
| MDL | MFCD06659911 |
4-Bromoindolin-2-one - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| Hazard Class | IRRITANT |
4-Bromoindolin-2-one - Introduction
4-Bromo-2-oxydole (4-Bromo-2-oxyindole) is an organic compound. Its chemical structure is Br-C6H3C4H2O. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 4-Bromo-2-oxyindole is a colorless or slightly yellow crystalline powder.
-Melting point: Its melting point range is 106-109°C.
-Solubility: It can be dissolved in common organic solvents, such as ethanol, dimethylthionamide and dichloromethane.
Use:
-Chemical synthesis: As an intermediate in organic synthesis, 4-Bromo-2-oxyindole can be used to synthesize other compounds, such as indole drugs and dyes.
-Scientific research: It can also be used in the field of scientific research, such as drug discovery and organic synthesis research.
Preparation Method:
The preparation of 4-Bromo-2-oxyindole can usually be carried out by the following steps:
1. take indole this organic molecule as a starting material.
2. Indole is reacted with lithium bromide (LiBr) in an appropriate organic solvent to replace one of the hydrogen atoms to form 4-bromoindole.
3. React 4-bromoindole with an appropriate oxidant, such as perbenzoic acid or N-bromosuccinimide (NBS), to introduce a ketone group to generate 4-Bromo-2-oxyindole.
Safety Information:
- 4-Bromo-2-oxyindole, as an organic compound, needs to be handled with caution. Appropriate protective measures should be taken during use and handling, such as wearing gloves, protective glasses and laboratory coats.
-Due to the lack of adequate toxicological information, the health risks of this compound are not known. Therefore, use should follow the safe practice, avoid inhalation, ingestion or contact with skin.
-During handling and storage, avoid contact with oxidants and combustibles to prevent fire or explosion.
-In case of accidental exposure or discomfort, seek medical help immediately and provide safety data for the relevant compound for the doctor's reference.
Please note that the above information is for reference only. When conducting experiments and using chemical substances, please follow correct safety procedures and refer to reliable chemical safety materials and related materials.
Nature:
-Appearance: 4-Bromo-2-oxyindole is a colorless or slightly yellow crystalline powder.
-Melting point: Its melting point range is 106-109°C.
-Solubility: It can be dissolved in common organic solvents, such as ethanol, dimethylthionamide and dichloromethane.
Use:
-Chemical synthesis: As an intermediate in organic synthesis, 4-Bromo-2-oxyindole can be used to synthesize other compounds, such as indole drugs and dyes.
-Scientific research: It can also be used in the field of scientific research, such as drug discovery and organic synthesis research.
Preparation Method:
The preparation of 4-Bromo-2-oxyindole can usually be carried out by the following steps:
1. take indole this organic molecule as a starting material.
2. Indole is reacted with lithium bromide (LiBr) in an appropriate organic solvent to replace one of the hydrogen atoms to form 4-bromoindole.
3. React 4-bromoindole with an appropriate oxidant, such as perbenzoic acid or N-bromosuccinimide (NBS), to introduce a ketone group to generate 4-Bromo-2-oxyindole.
Safety Information:
- 4-Bromo-2-oxyindole, as an organic compound, needs to be handled with caution. Appropriate protective measures should be taken during use and handling, such as wearing gloves, protective glasses and laboratory coats.
-Due to the lack of adequate toxicological information, the health risks of this compound are not known. Therefore, use should follow the safe practice, avoid inhalation, ingestion or contact with skin.
-During handling and storage, avoid contact with oxidants and combustibles to prevent fire or explosion.
-In case of accidental exposure or discomfort, seek medical help immediately and provide safety data for the relevant compound for the doctor's reference.
Please note that the above information is for reference only. When conducting experiments and using chemical substances, please follow correct safety procedures and refer to reliable chemical safety materials and related materials.
Last Update：2024-04-09 21:04:16
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