4-Bromopyridin-3-amine
3-Amino-4-bromopyridine
CAS: 239137-39-4
Molecular Formula: C5H5BrN2
4-Bromopyridin-3-amine - Names and Identifiers
| Name | 3-Amino-4-bromopyridine |
| Synonyms | 4-Brompyridin-3-amin 4-Bromopyridin-3-amine 4-Bromo-3-pyridinamine 4-bromopyridin-3-amine 4-BROMO-3-AMINOPYRIDINE 2,2-difluoropropan-1-ol 4-BROMOPYRIDINE-3-AMINE 4-Bromo- 3-pyridinamine 3-AMINO-4-BROMOPYRIDINE 3-Amino-4-bromopyridine 3-pyridinamine, 4-bromo- 4-BROMO-PYRIDIN-3-YLAMINE |
| CAS | 239137-39-4 |
| EINECS | 678-655-2 |
| InChI | InChI=1/C3H6F2O/c1-3(4,5)2-6/h6H,2H2,1H3 |
4-Bromopyridin-3-amine - Physico-chemical Properties
| Molecular Formula | C5H5BrN2 |
| Molar Mass | 173.01 |
| Density | 1.710±0.06 g/cm3(Predicted) |
| Boling Point | 287.6±20.0 °C(Predicted) |
| Flash Point | 8.388°C |
| Vapor Presure | 34.741mmHg at 25°C |
| Appearance | White solid |
| pKa | 3.88±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.333 |
4-Bromopyridin-3-amine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Hazard Class | IRRITANT |
4-Bromopyridin-3-amine - Introduction
3-Amino-4-bromopyridine is an organic compound with the chemical formula C5H5BrN2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 3-Amino-4-bromopyridine is a white to pale yellow crystalline solid.
-Solubility: insoluble in water, but soluble in organic solvents such as alcohols, ethers and chlorinated hydrocarbons.
-Melting point: Its melting point range is 50-53 degrees Celsius.
-Toxicity: 3-Amino-4-bromopyridine is a toxic compound, please follow the relevant laboratory safety procedures for use.
Use:
- 3-Amino-4-bromopyridine is an important organic synthesis intermediate, commonly used in the synthesis of drugs and pesticides.
-It can be used in the preparation of pesticides, antitumor drugs, antiviral drugs and other pharmaceutical compounds.
-In addition, it can also be used as a ligand in catalysts and metal ligands.
Method:
The preparation of 3-Amino-4-bromopyridine can usually be done by the following methods:
1. Use pyridine and hydrochloric acid to react to generate 3-chloropyridine.
2.3-chloropyridine reacts with bromide to generate 3-bromopyridine in the presence of base.
3. Finally, 3-bromopyridine is treated with ammonia water or ammonia gas to obtain 3-Amino-4-bromopyridine product.
Safety Information:
-Since 3-Amino-4-bromopyridine is a toxic substance, please use it in a suitable laboratory environment and comply with relevant safety procedures.
-Avoid inhalation, ingestion or contact with skin and eyes.
-during use, be sure to be equipped with appropriate personal protective equipment, such as protective glasses, gloves, protective clothing, etc.
-When storing and handling, please ensure that it is stored separately from oxidants, acids and other substances that should react to avoid accidents.
Nature:
-Appearance: 3-Amino-4-bromopyridine is a white to pale yellow crystalline solid.
-Solubility: insoluble in water, but soluble in organic solvents such as alcohols, ethers and chlorinated hydrocarbons.
-Melting point: Its melting point range is 50-53 degrees Celsius.
-Toxicity: 3-Amino-4-bromopyridine is a toxic compound, please follow the relevant laboratory safety procedures for use.
Use:
- 3-Amino-4-bromopyridine is an important organic synthesis intermediate, commonly used in the synthesis of drugs and pesticides.
-It can be used in the preparation of pesticides, antitumor drugs, antiviral drugs and other pharmaceutical compounds.
-In addition, it can also be used as a ligand in catalysts and metal ligands.
Method:
The preparation of 3-Amino-4-bromopyridine can usually be done by the following methods:
1. Use pyridine and hydrochloric acid to react to generate 3-chloropyridine.
2.3-chloropyridine reacts with bromide to generate 3-bromopyridine in the presence of base.
3. Finally, 3-bromopyridine is treated with ammonia water or ammonia gas to obtain 3-Amino-4-bromopyridine product.
Safety Information:
-Since 3-Amino-4-bromopyridine is a toxic substance, please use it in a suitable laboratory environment and comply with relevant safety procedures.
-Avoid inhalation, ingestion or contact with skin and eyes.
-during use, be sure to be equipped with appropriate personal protective equipment, such as protective glasses, gloves, protective clothing, etc.
-When storing and handling, please ensure that it is stored separately from oxidants, acids and other substances that should react to avoid accidents.
Last Update：2024-04-09 21:04:16
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CAS: 239137-39-4
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CAS: 239137-39-4
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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