4-Chloro-5-amino-6-(methylamino)pyrimidine

4-Chloro-5-amino-6-(methylamino)pyrimidine - Names and Identifiers

Name	6-chloro-N~4~-methylpyrimidine-4,5-diamine
Synonyms	6-Chloro-N4-methyl-4,5-pyrimidinediamine 6-Chloro-N-Methyl-Pyrimidine-4,5-Diamine 6-chloro-N-methyl-pyrimidine-4,5-diamine 6-chloro-N~4~-methylpyrimidine-4,5-diamine 6-Chloro-N~4~-methylpyrimidine-4,5-diamine 4-(Methylamino)-5-amino-6-chloropyrimidine 5-Amino-6-chloro-4-(methylamino)pyrimidine 4-Chloro-5-amino-6-(methylamino)pyrimidine 4,5-Pyrimidinediamine, 6-chloro-N4-methyl- 4,5-pyrimidinediamine, 6-chloro-N~4~-methyl- 6-chloro-4-Methyl-4,5-dihydropyriMidine-4,5-diaMine
CAS	52602-68-3
InChI	InChI=1/C5H7ClN4/c1-8-5-3(7)4(6)9-2-10-5/h2H,7H2,1H3,(H,8,9,10)

4-Chloro-5-amino-6-(methylamino)pyrimidine - Physico-chemical Properties

Molecular Formula	C5H7ClN4
Molar Mass	158.59
Density	1.447
Melting Point	62℃
Boling Point	328.2°C at 760 mmHg
Flash Point	152.3°C
Vapor Presure	0.000192mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.675
MDL	MFCD07364174

4-Chloro-5-amino-6-(methylamino)pyrimidine - Introduction

6-chloro-N ~ 4 ~-methylpyrimidine-4,5-diamine is an organic compound with the chemical formula C5H7ClN4.

The properties of the compound are as follows:
Appearance: White solid
Melting Point: 169-171°C
Boiling point: 354.3°C
Density: 1.49g/cm³

6-choro-N ~ 4 ~-methylpyrimidine-4,5-diamine is widely used in the field of drug synthesis and pesticide synthesis.

The preparation of the compound generally takes the following steps:
First, methylaminimidazole (N-methylaminomethylimidazole) was prepared by reaction of formaldehyde, ammonia and 2-pyridyl-1-methyl-imidazole (PMI) under alkaline conditions. The N-methylaminomethylimidazole is then reacted with 2-chloropyridine to give 4-chloro-5-methylaminoimidazole (4-chloroo-5-(methylamino)methylimidazole). Finally, through nucleophilic substitution reaction, 4-chloro-5-methylaminimidazole and amino chloride were used as raw materials to obtain 6-chloro-N ~ 4 ~-methylpyrimidine-4,5-diamine.

Regarding safety information, the toxicological properties of 6-choro-N ~ 4 ~-methylpyrimidine-4 and 5-diamine have not been fully studied, so close attention should be paid to safe handling and appropriate personal protective equipment should be worn. At the same time, the compound may cause certain harm to the environment and prevent it from entering the water and soil. During storage and transportation, care should be taken to avoid contact with oxidants, acidic substances and strong oxidants to avoid dangerous reactions.

Last Update：2024-04-09 21:11:58