4-Chloro-6-methoxyquinoline
4-Chloro-6-methoxyquinoline
CAS: 4295-04-9
Molecular Formula: C10H8ClNO
4-Chloro-6-methoxyquinoline - Names and Identifiers
| Name | 4-Chloro-6-methoxyquinoline |
| Synonyms | 4-CHLORO-6-METHOXYQUINOLINE 4-Chloro-6-methoxyquinoline 6-Methoxy-4-chloro quinoline Quinoline, 4-chloro-6-methoxy- |
| CAS | 4295-04-9 |
| InChI | InChI=1/C10H8ClNO/c1-13-7-2-3-10-8(6-7)9(11)4-5-12-10/h2-6H,1H3 |
4-Chloro-6-methoxyquinoline - Physico-chemical Properties
| Molecular Formula | C10H8ClNO |
| Molar Mass | 193.63 |
| Density | 1.267±0.06 g/cm3(Predicted) |
| Melting Point | 79-79.5 °C |
| Boling Point | 299.9±20.0 °C(Predicted) |
| Flash Point | 135.2°C |
| Vapor Presure | 0.00207mmHg at 25°C |
| pKa | 3.61±0.16(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.621 |
4-Chloro-6-methoxyquinoline - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| Hazard Class | IRRITANT |
4-Chloro-6-methoxyquinoline - Introduction
4-Chloro-6-methoxyquinoline is an organic compound. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Molecular formula: C10H8ClNO
-Molecular weight: 201.63g/mol
-Appearance: White crystal or crystalline powder
-Melting Point: 78-82°C
-Boiling Point: No clear boiling point data
-Solubility: Dissolved in most organic solvents, insoluble in water
Use:
4-Chloro-6-methoxyquinoline has antibacterial and antiparasitic activity. Due to its antimicrobial and antimalarial properties, it has potential applications in the medical field. In addition, it can also be used in organic synthesis as an important intermediate.
Preparation Method:
The preparation method of 4-Chloro-6-methoxyquinoline can be carried out by the following steps:
1.2-nitro -4-chloro-acetophenone is reacted with methanol to obtain 2-amino -4-chloro -6-methoxybenzene under reduction conditions.
2. Reaction of 2-amino-4-chloro-6-methoxybenzene with acetone to form 4-Chloro-6-methoxyquinoline.
Safety Information:
Specific safety information for 4-Chloro-6-methoxyquinoline requires reference to the relevant safety data sheet. When using this compound, you must follow appropriate laboratory safety procedures and take necessary personal protective measures to avoid contact with skin, eyes and inhalation. At the same time, this compound should be stored in a sealed container and away from heat and fire sources. If necessary, the operation should be carried out in a well-ventilated place.
Nature:
-Molecular formula: C10H8ClNO
-Molecular weight: 201.63g/mol
-Appearance: White crystal or crystalline powder
-Melting Point: 78-82°C
-Boiling Point: No clear boiling point data
-Solubility: Dissolved in most organic solvents, insoluble in water
Use:
4-Chloro-6-methoxyquinoline has antibacterial and antiparasitic activity. Due to its antimicrobial and antimalarial properties, it has potential applications in the medical field. In addition, it can also be used in organic synthesis as an important intermediate.
Preparation Method:
The preparation method of 4-Chloro-6-methoxyquinoline can be carried out by the following steps:
1.2-nitro -4-chloro-acetophenone is reacted with methanol to obtain 2-amino -4-chloro -6-methoxybenzene under reduction conditions.
2. Reaction of 2-amino-4-chloro-6-methoxybenzene with acetone to form 4-Chloro-6-methoxyquinoline.
Safety Information:
Specific safety information for 4-Chloro-6-methoxyquinoline requires reference to the relevant safety data sheet. When using this compound, you must follow appropriate laboratory safety procedures and take necessary personal protective measures to avoid contact with skin, eyes and inhalation. At the same time, this compound should be stored in a sealed container and away from heat and fire sources. If necessary, the operation should be carried out in a well-ventilated place.
Last Update：2024-04-09 21:11:58
