4-Chloro-6-quinolinol
4-chloroquinolin-6-ol
CAS: 148018-29-5
Molecular Formula: C9H6ClNO
4-Chloro-6-quinolinol - Names and Identifiers
| Name | 4-chloroquinolin-6-ol |
| Synonyms | 4-Chloroquinolin-6-ol 4-Chloro-6-quinolinol 4-chloroquinolin-6-ol 6-Quinolinol, 4-chloro- 6-quinolinol, 4-chloro- 4-Chloro-6-hydroxyquinoline |
| CAS | 148018-29-5 |
| InChI | InChI=1/C9H6ClNO/c10-8-3-4-11-9-2-1-6(12)5-7(8)9/h1-5,12H |
4-Chloro-6-quinolinol - Physico-chemical Properties
| Molecular Formula | C9H6ClNO |
| Molar Mass | 179.6 |
| Density | 1.412g/cm3 |
| Boling Point | 304.9°C at 760 mmHg |
| Flash Point | 138.2°C |
| Vapor Presure | 0.00047mmHg at 25°C |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.696 |
4-Chloro-6-quinolinol - Introduction
4-chloroquinolin-6-ol is an organic compound with the chemical formula C9H6ClNO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-chloroquinolin-6-ol is a white crystalline solid.
-Solubility: The solubility in water is low, but the solubility in organic solvents is high.
-Melting point and boiling point: melting point is 158-159 ℃, boiling point is 332 ℃.
Use:
4-chloroquinolin-6-ol is an important intermediate in organic synthesis and is often used to prepare other compounds. Specific uses include:
-Pesticides: can be used as a synthetic raw material for some pesticides.
-Drugs: Used to synthesize certain drugs, such as anti-cancer drugs.
Method:
4-chloroquinolin-6-ol has various preparation methods, the most common methods are as follows:
1. Reacting 4-chloro-6-nitroquinoline with sulfoxide to obtain an amino compound.
2. The amino compound is reduced to aminoquinoline.
3. 4-Amino-6-hydroxyquinoline is obtained by aminomethylation reaction.
4. Finally, 4-amino-6-hydroxyquinoline chloride was substituted for 4-chloroquinolin-6-ol.
Safety Information:
- 4-chloroquinolin-6-ol may be irritating to the eyes, skin, and respiratory tract.
-Wear appropriate personal protective equipment such as gloves, goggles and masks during use and handling.
-Avoid inhaling powder or mist, avoid contact with skin and eyes.
-When using or storing, keep away from open flames and high temperatures, and maintain a well-ventilated environment.
-If skin or eye contact occurs, rinse immediately with plenty of water and seek medical help.
-Waste should be disposed of in accordance with local regulations to avoid environmental pollution.
Nature:
-Appearance: 4-chloroquinolin-6-ol is a white crystalline solid.
-Solubility: The solubility in water is low, but the solubility in organic solvents is high.
-Melting point and boiling point: melting point is 158-159 ℃, boiling point is 332 ℃.
Use:
4-chloroquinolin-6-ol is an important intermediate in organic synthesis and is often used to prepare other compounds. Specific uses include:
-Pesticides: can be used as a synthetic raw material for some pesticides.
-Drugs: Used to synthesize certain drugs, such as anti-cancer drugs.
Method:
4-chloroquinolin-6-ol has various preparation methods, the most common methods are as follows:
1. Reacting 4-chloro-6-nitroquinoline with sulfoxide to obtain an amino compound.
2. The amino compound is reduced to aminoquinoline.
3. 4-Amino-6-hydroxyquinoline is obtained by aminomethylation reaction.
4. Finally, 4-amino-6-hydroxyquinoline chloride was substituted for 4-chloroquinolin-6-ol.
Safety Information:
- 4-chloroquinolin-6-ol may be irritating to the eyes, skin, and respiratory tract.
-Wear appropriate personal protective equipment such as gloves, goggles and masks during use and handling.
-Avoid inhaling powder or mist, avoid contact with skin and eyes.
-When using or storing, keep away from open flames and high temperatures, and maintain a well-ventilated environment.
-If skin or eye contact occurs, rinse immediately with plenty of water and seek medical help.
-Waste should be disposed of in accordance with local regulations to avoid environmental pollution.
Last Update：2024-04-09 21:00:56
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