4-Chloro-o-Toluidine
4-Chloro-2-methylaniline
CAS: 95-69-2
Molecular Formula: C7H8ClN
4-Chloro-o-Toluidine - Names and Identifiers
| Name | 4-Chloro-2-methylaniline |
| Synonyms | fast red TR base 4-Chloro-o-Toluidine 2-AMINO-5-CHLORTOLUENE 2-AMINO-5-CHLOROTOLUENE 2-Amino-5-chlorotoluene 4-Chloro-6-methylaniline 4-Chloro-2-methylaniline 4-CHLORO-O-METHYLANILINE 2-methyl-4-chloroaniline 1-AMINO-4-CHLORO-6-METHYLBENZENE 4-Chloro-2-Methylaniline (4-Chloro-O-Toluidine)4,4'-Benzidine 2-Amino-5-chlorotoluene4-Chloro-o-toluidine4-Chloro-2-methylanilineFast Red TR Base5-Chloro-2-aminotoluene2-Methyl-4-chloroaniline |
| CAS | 95-69-2 |
| EINECS | 202-441-6 |
| InChI | InChI=1/C7H8ClN/c1-5-4-6(8)2-3-7(5)9/h2-4H,9H2,1H3 |
4-Chloro-o-Toluidine - Physico-chemical Properties
| Molecular Formula | C7H8ClN |
| Molar Mass | 141.6 |
| Density | 1.19 g/mL at 25 °C (lit.) |
| Melting Point | 24-27 °C (lit.) |
| Boling Point | 241 °C (lit.) |
| Flash Point | 211°F |
| Water Solubility | Practically insoluble in water |
| Appearance | Transparent brown liquid |
| Color | White or colorless to Brown |
| BRN | 878505 |
| pKa | pK1:3.385(+1) (25°C) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | n20/D 1.583(lit.) |
| MDL | MFCD00007842 |
| Physical and Chemical Properties | Density 1.14 melting point 27°C boiling point 241°C refractive index 1.5845-1.5865 flash point 99°C |
4-Chloro-o-Toluidine - Risk and Safety
| Risk Codes | R45 - May cause cancer R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R68 - Possible risk of irreversible effects |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 2239 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | XU5000000 |
| FLUKA BRAND F CODES | 8-10 |
| HS Code | 29214300 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
4-Chloro-o-Toluidine - Reference Information
| (IARC) carcinogen classification | 2A (Vol. 77, 99) 2010 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| uses | important intermediates for pesticides, pharmaceuticals and dyes. used as pesticide and pharmaceutical intermediates |
| production method | is obtained by chlorination of o-toluidine. A variety of chlorination methods are available. O-toluidine hydrochloride 4-chloro-o-toluidine can be obtained by chlorine reaction using chlorobenzene as solvent at 50-60 ℃. It can also be obtained by acylation followed by chlorination and hydrolysis. O-toluidine and chlorobenzene were mixed and stirred, acetic anhydride was added dropwise, the reaction was stirred at 70-80 ° C. For 1.5h, cooled, and chlorine was passed at about 50 ° C., at which time a large amount of white solid was suddenly generated. The passage of chlorine was stopped, concentrated hydrochloric acid and water were added, and the mixture was stirred and refluxed at 95 ° C. For 2H. It was cooled to room temperature and neutralized with alkali solution. The yield was more than 70%. Another method is to react o-toluidine hydrochloride with a mixed gas of hydrogen chloride and oxygen (or chlorine and oxygen) in an acidic medium. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:48:19
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